"A definitive diagnosis requires a fulminant, monophasic demyelinating event characterised by rapid neurological deterioration occurring over hours to weeks. This episode typically results in early, severe disability (often reflected by an Expanded Disability Status Scale (EDSS) score of > 6) in patients with no prior history of a relapsing-remitting MS course 5."
"Baló concentric sclerosis (BCS)"
"Marburg type MS typically is rapidly progressive, fulminant, and often results in death from involvement of the brainstem or due to marked mass effect and herniation 2,4. While first-line management generally consists of pulse intravenous corticosteroid therapy, a significant proportion of cases remain refractory. In such instances, intravenous immunoglobulin or plasmapheresis may be utilised; both modalities have demonstrated clinical efficacy in improving patient outcomes within specific cohorts 5."