"Medulloblastoma - group 4 tumours are malignant tumours of the central nervous system, and one of the most common paediatric tumours. They are the most common medulloblastoma group (followed by group 3, SHH-activated, and WNT-activated), and typically arise from the vermis of the cerebellum."
"Medulloblastoma - group 4 tumours are malignant tumours of the central nervous system, and one of the most common paediatric tumours. They are the most common medulloblastoma group (followed by group 3, SHH-activated, and WNT-activated), and typically arise from the vermis of the cerebellum."
"The nomenclature and classification of medulloblastomas are rapidly evolving. In the 5th edition (2021) of the WHO classification of CNS tumours, group 3 and group 4 medulloblastomas are grouped together under non-WNT/non-SHH tumours, which is in turn divided into 8 subgroups 5."
"The nomenclature and classification of medulloblastomas are rapidly evolving. In the 5th edition (2021) of the WHO classification of CNS tumours, group 3 and group 4 medulloblastomas are grouped together under non-WNT/non-SHH tumours, which is in turn divided into 8 subgroups 5."
"They are most frequently encountered in children (4-16 years of age), not infrequently in adults (second only to SHH in frequency) and are uncommon in infants 1."
"Overall, group 4 tumours have a poor prognosis, somewhat better than group 3 tumours, but significantly worse than SHH and WNT subtypes 1,2. In adults, the prognosis is very poor, whereas in children it is intermediate 4."
"Overall, group 4 tumours have a poor prognosis, somewhat better than group 3 tumours, but significantly worse than SHH and WNT subtypes 1,2. In adults, the prognosis is very poor, whereas in children it is intermediate 4."
"The radiographic features of group 4 tumours are those that we typically associate with medulloblastomas; midline masses arising from the vermis. They are fairly well defined with limited contrast enhancement 3."