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Lint: mucin-containing-rectal-cancer

mucin-containing-rectal-cancer
Acronyms
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"Mucinous adenocarcinoma contains extracellular mucin pools surrounded by neoplastic epithelial cells. It is associated with molecular features that differ from conventional adenocarcinoma, including increased frequencies of BRAF and KRAS mutations, MUC2 overexpression and microsatellite instability 1."

Line 23:228 · 'BRAF' has no definition. Spell it out if it's unfamiliar to the audience.

"Mucinous adenocarcinoma contains extracellular mucin pools surrounded by neoplastic epithelial cells. It is associated with molecular features that differ from conventional adenocarcinoma, including increased frequencies of BRAF and KRAS mutations, MUC2 overexpression and microsatellite instability 1."

Line 23:237 · 'KRAS' has no definition. Spell it out if it's unfamiliar to the audience.
List Caps
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"T category, depth of extramural spread and relationship to the mesorectal fascia"

Line 76:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Mucinous adenocarcinoma"

Line 22:1 · "Mucinous adenocarcinoma" is not a recognised heading for this article type.

"Signet ring cell carcinoma"

Line 24:1 · "Signet ring cell carcinoma" is not a recognised heading for this article type.

"Post-treatment mucinous degeneration"

Line 26:1 · "Post-treatment mucinous degeneration" is not a recognised heading for this article type.

"Mucinous adenocarcinoma"

Line 30:1 · "Mucinous adenocarcinoma" is not a recognised heading for this article type.

"Signet ring cell carcinoma"

Line 40:1 · "Signet ring cell carcinoma" is not a recognised heading for this article type.

"Post-treatment assessment"

Line 50:1 · "Post-treatment assessment" is not a recognised heading for this article type.

"PET-CT"

Line 64:1 · "PET-CT" should be H3, not H2.

"Metastatic disease and recurrence"

Line 66:1 · "Metastatic disease and recurrence" is not a recognised heading for this article type.
Oxford Comma
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"Signet ring cell carcinoma contains abundant intracytoplasmic mucin that displaces the nucleus to the cell periphery. It is an undifferentiated, high-grade tumour with a propensity for lymphatic, vascular and perineural invasion. It typically spreads within the submucosa and may produce a rectal linitis plastica pattern 1,2."

Line 25:189 · Use the Oxford comma in 'lymphatic, vascular and perineural'.

"tumour length, location and relationship to the anal verge, anorectal junction and anterior peritoneal reflection"

Line 75:15 · Use the Oxford comma in 'length, location and relationship'.

"describe residual intermediate-signal, enhancing or diffusion-restricting components"

Line 85:39 · Use the Oxford comma in 'signal, enhancing or diffusion'.

"Signet ring cell carcinoma is aggressive, frequently presents with advanced local, nodal or metastatic disease and generally has the poorest prognosis of the mucin-containing subtypes. Advanced nodal disease is associated with worse disease-free survival 1,2."

Line 92:80 · Use the Oxford comma in 'local, nodal or metastatic'.

"The prognostic importance of post-treatment mucinous degeneration remains uncertain. Although previously considered a favourable response marker, a more recent cohort found no significant association with complete pathological response, recurrence or overall survival. It must not be regarded as evidence of complete response 3."

Line 93:231 · Use the Oxford comma in 'response, recurrence or overall'.

"conventional rectal adenocarcinoma with necrosis, oedema or treatment-related change"

Line 96:48 · Use the Oxford comma in 'necrosis, oedema or treatment'.

"secondary rectal linitis plastica from direct invasion or metastatic gastric, breast, bladder or prostate malignancy"

Line 98:86 · Use the Oxford comma in 'breast, bladder or prostate'.

"mucinous metastasis involving the rectum, particularly from colonic, gastric or ovarian primary tumours"

Line 99:68 · Use the Oxford comma in 'colonic, gastric or ovarian'.
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