"limits of conventional MRI technique: it is less sensitive to the associated diffuse damage in normal-appearing white matter.5 In fact, normal-appearing white matter in post-mortem studies of patients with MS - despite retaining myelin - often exhibits chronic injury.6 Advanced MRI techniques such as diffusion tensor imaging (DTI) has shown promise as more specific."
"limits of conventional MRI technique: it is less sensitive to the associated diffuse damage in normal-appearing white matter.5 In fact, normal-appearing white matter in post-mortem studies of patients with MS - despite retaining myelin - often exhibits chronic injury.6 Advanced MRI techniques such as diffusion tensor imaging (DTI) has shown promise as more specific."
"epidemiology"
"presentation"
"clinically isolated syndrome (CIS); isolated neurological deficit with a solitary plaque on imaging; progression to MS is not certain"
"relapsing-remitting (RRMS); 70% of cases; on-off periods of symptoms with a full resolution in between flares"
"relapsing-remitting (RRMS); 70% of cases; on-off periods of symptoms with a full resolution in between flares"
"secondary progressive (SPMS); progression of symptoms in RRMS with the deterioration of baseline functioning"
"primary progressive (PPMS); progressive deterioration from diagnosis; little or no remission"
"pathophysiology"
"investigation"
"treatment"
"role of imaging"
"radiographic features"
"clinically isolated syndrome (CIS); isolated neurological deficit with a solitary plaque on imaging; progression to MS is not certain"
"relapsing-remitting (RRMS); 70% of cases; on-off periods of symptoms with a full resolution in between flares"
"secondary progressive (SPMS); progression of symptoms in RRMS with the deterioration of baseline functioning"
"secondary progressive (SPMS); progression of symptoms in RRMS with the deterioration of baseline functioning"
"primary progressive (PPMS); progressive deterioration from diagnosis; little or no remission"
"lesions may occur throughout the CNS and be found in a variety of locations, e.g. juxtacortical, brainstem, cerebellum, or spinal cord (also part of the CNS)"
Expected headings
"This is a basic article for medical students and other non-radiologists"
"Imaging"
"This is a summary article; read more in our article on multiple sclerosis."
"clinically isolated syndrome (CIS); isolated neurological deficit with a solitary plaque on imaging; progression to MS is not certain"
"clinically isolated syndrome (CIS); isolated neurological deficit with a solitary plaque on imaging; progression to MS is not certain"
"relapsing-remitting (RRMS); 70% of cases; on-off periods of symptoms with a full resolution in between flares"
"secondary progressive (SPMS); progression of symptoms in RRMS with the deterioration of baseline functioning"
"primary progressive (PPMS); progressive deterioration from diagnosis; little or no remission"
"primary progressive (PPMS); progressive deterioration from diagnosis; little or no remission"