"Multisystem inflammatory syndrome in children (MIS-C) or paediatric inflammatory multisystem syndrome (PIMS) is an emerging paediatric disease occurring after prior SARS-CoV-2 infection and is therefore strongly associated with the ongoing COVID-19 pandemic."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"Typically MIS-C occurs with at least 1 to 2 weeks delay after the triggering SARS-CoV-2 infection 2."
"Abdominal US may show ascites, signs of intestinal inflammation (predominantly distal ileal and caecal bowel wall thickening), or mesenteric adenopathy (primarily in the right iliac fossa). Increased periportal echogenicity, pericholecystic oedema, moderate gallbladder wall thickening, sludge, hepatomegaly or splenomegaly, hypoechoic splenic lesions/infarcts are less common. Acute kidney injury, manifesting as increased echogenicity, occurs occasionally. On abdominal CT, mesenteric fat stranding, along with typical right lower quadrant lymphadenopathy, may be seen 3."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"The World Health Organisation and the US Centres for Disease Control and Prevention both use the name multisystem inflammatory system in children (MIS-C) for this condition, and thus so will this article, but terminology varies. The UK Royal College of Paediatrics and Child Health uses the name paediatric multisystem inflammatory syndrome temporally associated with Covid-19 (abbreviated PIMS or PIMS-TS) 4."
"Hyperinflammatory systemic shock due to the prior infection is considered to be the culprit behind MIS-C. The severity of the prior COVID-19 infection is not considered to be a strong predictor, as MIS-C can develop even after completely asymptomatic infections 1."
Expected headings
"Cardiac"
"Chest"
"Abdominal"
"Neurologic"
"Musculoskeletal"
"MIS-C affects multiple anatomical structures; thus, in the following section, findings are summarised based on body regions:"
"Abdominal US may show ascites, signs of intestinal inflammation (predominantly distal ileal and caecal bowel wall thickening), or mesenteric adenopathy (primarily in the right iliac fossa). Increased periportal echogenicity, pericholecystic oedema, moderate gallbladder wall thickening, sludge, hepatomegaly or splenomegaly, hypoechoic splenic lesions/infarcts are less common. Acute kidney injury, manifesting as increased echogenicity, occurs occasionally. On abdominal CT, mesenteric fat stranding, along with typical right lower quadrant lymphadenopathy, may be seen 3."