"The incidence is ~0.6 (meningeal) and ~0.4 (extra-meningeal) per million persons per year 14. Solitary fibrous tumours occur at essentially any age but are uncommon in childhood and somewhat more common in the 5th to 7th decades 13,14. Tumours of the pleura are reported in slightly older age groups 13 although this may be due to a combination of delayed presentation and the heterogeneity of published series."
"BCL-2 (B-cell lymphoma 2 protein): a marker of terminal differentiation"
"Solitary fibrous tumours occur essentially anywhere, both within lined cavities (e.g. pleura, peritoneum, dura), solid organs (e.g. liver, spleen) and soft tissues (e.g. extremities, orbit, retroperitoneum). Some locations are more common than others 7,13:"
"Solitary fibrous tumours have variable cellularity but generally are composed of a collagenous matrix with arrays of spindle cells. Areas of necrosis, cystic or myxoid change, calcification, haemorrhage, increased vascularity, atypia, or malignancy may also be seen 7,8. Blood vessels often contain large calibre thin-walled branching staghorn blood vessels 13. More cellular tumours tend to represent higher grade lesions 13."
"Elsewhere, other sarcomas can appear very similar, including angiosarcoma, synovial sarcomas, malignant peripheral nerve sheath tumours, liposarcoma, etc. 13."
"Solitary fibrous tumours appear as sharply marginated multilobulated firm masses. The cut surface is dense and pale in colour although areas of fat, haemorrhage, necrosis and myxomatous change can be encountered especially in higher-grade tumours. These more aggressive tumours may also demonstrate less well-defined margins with infiltration into adjacent tissues 13."
"Solitary fibrous tumours have variable cellularity but generally are composed of a collagenous matrix with arrays of spindle cells. Areas of necrosis, cystic or myxoid change, calcification, haemorrhage, increased vascularity, atypia, or malignancy may also be seen 7,8. Blood vessels often contain large calibre thin-walled branching staghorn blood vessels 13. More cellular tumours tend to represent higher grade lesions 13."
"History and etymology"