"Photoacoustic imaging using endogenous chromophores can differentiate deoxyhaemoglobin and haemoglobin, directly visualising ischaemia/hypoxia. Similarly, tissue vascularity has been successfully performed (e.g. imaging of breast cancers, skin tumours, psoriatic skin lesions, wound healing, and inflammation of the small joints) 2-5."
"Although nanoparticles of various compositions (e.g. metallic, organic, inorganic semiconductor, and carbon) are potentially useful as targets of photoacoustic imaging, their potential toxicity has limited their study 7."
"A number of dyes are approved for clinical use by the FDA including indocyanine green, Evans blue and methylene blue 1,7."
Expected headings
"Endogenous chromophores"
"Exogenous chromophores"
"The most promising aspect of photoacoustic imaging in clinical imaging is its ability to selectively detect naturally occurring chromophores with distinct optical absorption spectra, such as haemoglobin, lipids, collagen and melanin 1,7."
"Photoacoustic imaging exploits thermoelastic expansion; the ability of certain compounds to absorb photons of specific wavelengths, converting this energy into heat and structural expansion. This expansion, in turn, results in pressure waves propagating away from the tissue. An ultrasound transducer can then detect these waves 7."