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"It usually affects the middle-aged to elderly, with a mean age of 60 years⁶. The estimated prevalence is ~1:100,000. There may be a slight male predilection¹² ."

Line 9:172 · Citations must have a preceding space, e.g. needs evidence 2. '12'

Citation Punctuation Space

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"It usually affects the middle-aged to elderly, with a mean age of 60 years⁶. The estimated prevalence is ~1:100,000. There may be a slight male predilection¹² ."

Line 9:172 · Citations should not have spaces between themselves and punctuation. '12 .'

Emphasis

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"It is a chronic clonal stem cell disorder of neoplastic megakaryocytes and is considered a BCR-ABL1 (breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1)-negative myeloproliferative disorder ¹¹."

Line 11:95 · Italics should be used only in exceptional circumstances: 'BCR-ABL1'

Acronyms

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"Progressive bone marrow fibrosis is the result of collagen produced by non-neoplastic fibroblasts in response to inappropriate release of PDGF and TGF-ß from the neoplastic megakaryocytes ⁸."

Line 12:151 · 'TGF' has no definition. Spell it out if it's unfamiliar to the audience.

Headings Valid

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