"Malignant melanoma of the uvea is the most common primary intraocular malignancy in adults, and is predominantly seen in those with a Northern European white ancestry 5,15. The incidence of these tumours generally increases with age, with only 2% of tumours found in patients younger than 20 years of age 6. The typical age of presentation is between 50-70 years 15. However, iris melanomas may more commonly present in a younger age demographic 15."
"BAP1-tumour predisposition syndrome 15"
"Primary uveal melanoma typically harbour somatic mutations in either GNAQ or GNA11 15. Following from this initial mutation, there is a subsequent somatic mutation known as a "BSE" event (BAP1, splice, EIF1AX mutations) that is thought to lead to oncogenicity 15. This genetic profile is distinct from cutaneous melanomas, which usually have BRAF or NRAS mutations instead 15."
"Systemic management options for metastatic disease are unfortunately limited 15. For example, one option is tebentafusp among HLA-A*02:01-positive adult patients 16."
"Primary uveal melanoma typically harbour somatic mutations in either GNAQ or GNA11 15. Following from this initial mutation, there is a subsequent somatic mutation known as a "BSE" event (BAP1, splice, EIF1AX mutations) that is thought to lead to oncogenicity 15. This genetic profile is distinct from cutaneous melanomas, which usually have BRAF or NRAS mutations instead 15."
"tumours may be irregular, lobulated or domed"