"MRI is the modality of choice for pre-treatment staging of retinoblastoma (see retinoblastoma staging) 4."
"T1: intermediate signal intensity, hyperintense compared to the vitreous 4,5"
"T2: hypointense compared to the vitreous"
"Retinoblastomas may be sporadic or secondary to a germline mutation of the retinoblastoma protein tumour suppressor gene (RB), which is usually inherited. Retinoblastoma may be unilateral or bilateral:"
"the tumour shows restricted diffusion on DWI at high b values. It exhibits low ADC values in contrast to the high values of the vitreous"
"Histology demonstrates a small round-cell tumour of neuroepithelial origin. Flexner-Wintersteiner rosettes (relatively specific for retinoblastoma) and Homer-Wright pseudorosettes (also found in other PNETs) may be seen on microscopy."
"extra-ocular extension through the sclera will be visible as an interruption of the otherwise hypointense non-enhancing sclera by enhancing tumour"
Expected headings
"Associations"
"Complications"
"The vitreous may have multiple areas of "floating" debris, which may represent vitreous seeding or alternatively, necrotic debris, haemorrhage or increased globulin content 5."