"Often asymptomatic and discovered incidentally on a chest radiograph. The radiographic features are disproportionate to the clinical symptoms 5, which can include:"
"See also "
"Pathogenic SLC34A2 variants have been identified in nearly all genetically tested patients. This causes inactivation of a sodium-dependent phosphate co-transporter, which is found mainly in alveolar type II cells. This co-transporter normally clears phosphate from degraded surfactant, and when inactivated there is accumulation of phosphate in the alveolus and calcium phosphate microliths are then thought to form 9."
Expected headings
"Associations"
"See also "
"Pulmonary alveolar microlithiasis is very rare, with an incidence varying between 0.06-1.85 per million people 13. Most cases are reported in Asia and Europe, especially Turkey, Italy and Japan 9,13. There is no significant gender predilection 13."
"chest pain exacerbated by coughing, sneezing or deep inspiration"
"Disease can progress to restrictive lung physiology, hypoxaemia and respiratory failure, pulmonary hypertension and cor pulmonale."
"Pulmonary alveolar microlithiasis is very rare, with an incidence varying between 0.06-1.85 per million people 13. Most cases are reported in Asia and Europe, especially Turkey, Italy and Japan 9,13. There is no significant gender predilection 13."
"Genetic testing for SLC34A2 mutations is the gold standard; bronchoalveolar lavage and histopathology being reserved for select cases where genetic confirmation is not feasible."
"idiopathic pulmonary haemosiderosis: tend to be large nodular opacities; no calcification 1"