"Prophylactic treatment consists of prompt treatment of the causative factor, e.g. fracture fixation. Treatment is largely supportive and involves fluid resuscitation, maintaining good arterial oxygenation and sufficient intravascular volume. Adding albumin to the electrolyte solution used for volume resuscitation can help bind the free fatty acids 8. Mechanical ventilation and PEEP may be required in certain cases. Symptoms are often transient with a good prognosis."
"production of free fatty acids, which initiates a toxic reaction in the endothelium; this process is further complicated by the accumulation of neutrophils and other inflammatory cells, which cause damage to the vasculature"