"Overall prognosis is variable, depending on the organ(s) involved and the severity. For patients with limited cutaneous involvement, 10-year survival is approximately 75%. However, patients with diffuse involvement have a 10-year survival closer to 55% 5."
"may identify patients with scleroderma-RA overlap syndrome, who in turn are more likely to develop joint erosions"
Expected headings
"Associations"
"Although presentation in childhood is indeed recognised 1, scleroderma is considered a disease of middle age (30-50 years of age) 3,4. There is a strong female predilection (F:M 3:1), even more pronounced during reproductive years (F:M 10:1) 2."