"Pathology "
"West Nile virus (WNV) is an arbovirus and one of the Flavivirus genus known to cause neuroinvasive disease, including Flavivirus encephalitis. According to the CDC, the majority of mosquito-borne disease in the continental United States is attributed to West Nile virus infection 1."
"West Nile virus is a single-stranded RNA of the genus Flavirirus and family Flaviviridae. Birds are the host organism and mosquitos, via their salivary glands, the vector of disease transmission."
"Infection by one of the pathogenic members of the Flavivirus genus may present similarly, including:"
"Epidemics have occurred along the migratory routes of birds in the US, Europe, Africa, the Middle East and West Asia 2. In history, frequency and severity of West Nile virus outbreaks are increasing 3. Of note, West Nile virus is implicated in the majority of viral encephalitis cases in the US 5."
"Epidemics have occurred along the migratory routes of birds in the US, Europe, Africa, the Middle East and West Asia 2. In history, frequency and severity of West Nile virus outbreaks are increasing 3. Of note, West Nile virus is implicated in the majority of viral encephalitis cases in the US 5."
"West Nile virus is a single-stranded RNA of the genus Flavirirus and family Flaviviridae. Birds are the host organism and mosquitos, via their salivary glands, the vector of disease transmission."
"Japanese encephalitis virus (Asia)"
"Murray Valley encephalitis (Australia, New Zealand, Papua New Guinea)"
"St Louis encephalitis virus (United States of America)"
"Rocio virus (Brazil)"
"Powassan virus (United States of America)"
Expected headings
"Pathology "
"Epidemics have occurred along the migratory routes of birds in the US, Europe, Africa, the Middle East and West Asia 2. In history, frequency and severity of West Nile virus outbreaks are increasing 3. Of note, West Nile virus is implicated in the majority of viral encephalitis cases in the US 5."
"encephalitis, bowel and bladder dysfunction often occur in conjunction"
"encephalitis, meningitis or encephalomeningitis"
"presenting symptoms including headache, neck stiffness, somnolence, coma, movement disorder, confusion and seizures 3,4"
"Presentation varies with the severity of response to West Nile virus infection. The majority will remain asymptomatic. Approximately 20% will develop classical symptoms of a viral fever - or West Nile fever in this case - including fever, malaise, fatigue, myalgia, arthralgia, retro-orbital pain, maculopapular rash and lymphadenopathy 3,4."
"presenting symptoms including headache, neck stiffness, somnolence, coma, movement disorder, confusion and seizures 3,4"
"hyperintensity within deep brain structures, including the thalami, basal ganglia and midbrain structures 5; the latter includes the red nucleus, cerebral peduncle and substantia nigra"
"Strategies to limit infection at an individual level include wearing protective clothing, using mosquito repellent and staying indoors during peak vector activity periods; while strategies at a population level include coordinated mosquito surveillance programs and insecticide treatments 8,9."
"Treatment is supportive. There are no vaccines against the West Nile virus that are approved for use in humans 7,8."