"CT usually shows a fat tissue density mass with thick or nodular enhancing septae. Calcifications might be rarely found 4."
"T1: hyperintense"
"T2: hyperintense, possibly with prominent high signal foci"
"T2FS/PDFS: hypointense"
"T1 C+ (Gd): moderate to marked enhancement of septa"
"Atypical lipomatous tumours / well-differentiated liposarcomas (ALT/WDLPS) are locally aggressive adipocytic soft tissue neoplasms and are the most common form of liposarcomas."
"Atypical lipomatous tumours / well-differentiated liposarcomas (ALT/WDLPS) are locally aggressive adipocytic soft tissue neoplasms and are the most common form of liposarcomas."
">13 cm (specific MRI-derived threshold for distinguishing ALT from lipoma) 7, 17"
"MDM2 and/or CDK4 gene amplification"
"T1 C+ (Gd): moderate to marked enhancement of septa"
"Atypical lipomatous tumours or well-differentiated liposarcomas account for 40-45% of liposarcomas and constitute the largest subgroup of adipocyte malignancies. They occur mostly in middle-aged adults. They are extremely rare in childhood. Inguinal lesions are more common in men; otherwise, there is no gender predominance 1-3."
"Radiotherapy has generally very limited efficacy as a primary treatment; it may be considered as an adjunctive therapy in selected cases (e.g. retroperitoneal tumours), as decided by the multidisciplinary team 18,19."
"form, location and size"
"Tumours of the mediastinum, retroperitoneum or spermatic cord have a worse prognosis, due to their location, they are also more prone to local recurrence 1,2. On the other hand, patients with tumours affecting the extremities have a very good prognosis with >90% survival after 10 years of follow-up and thus the name atypical lipomatous tumour 8. For selected patients with atypical lipomatous tumours of the extremities, active surveillance has been suggested as a viable option to prevent overtreatment 8."
"Liposarcomas were first reported by the German pathologist Rudolph Virchow in 1857, who called them "myxoma lipomatodes malignum" 9,10. After the 1950s, a further classification of liposarcoma into the well-differentiated, myxoid and dedifferentiated was suggested 11-15. The terms atypical lipoma or atypical lipomatous tumour, of which the former is no longer recommended 1 have been introduced by the American pathologist Harry L Evans in 1979 14,15."