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Lint: li-fraumeni-syndrome-2

li-fraumeni-syndrome-2
Emphasis
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"Li-Fraumeni syndrome is a hereditary cancer syndrome due to mutations in the tumour suppressor gene TP53. Approximately half of affected individuals are thought to develop invasive cancer by 30 years of age 1."

Line 1:124 · Italics should be used only in exceptional circumstances: '<em>TP53</em>'

"The incidence of Li-Fraumeni syndrome (LFS), is approximately 1 in 5,000 to 1 in 20,000 individuals, around 0.8% or more in unselected paediatric cancer patients, and up to 10.4% among children whose tumours harbour TP53 variants."

Line 3:220 · Italics should be used only in exceptional circumstances: '<em>TP53</em>'
Headings Case
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"Treatment and Prognosis"

Line 22:5 · 'Treatment and Prognosis' should use sentence-style capitalization.
Acronyms
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"The disorder was described in 1969 by the cancer geneticists Frederick Li and Joseph Fraumeni, Jr, who were then working at the National Cancer Institute in Maryland, USA 2."

Line 33:205 · 'USA' has no definition. Spell it out if it's unfamiliar to the audience.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Treatment and Prognosis"

Line 22:1 · "Treatment and Prognosis" is not a recognised heading for this article type.
Semicolons
suggestion

"adrenocortical carcinoma (ACC) - 50-80% of ACCs presenting in childhood are linked to LFS; children often present with virilisation or Cushing syndrome"

Line 10:104 · Use semicolons judiciously.

"42% of individuals with Li-Fraumeni syndrome die from cancer; most of these individuals die before age 60 5"

Line 30:68 · Use semicolons judiciously.
Biographical Lifespan
suggestion

"History and etymology"

Line 32:1 · A bold element in the History and etymology section should be a person; it would be useful to have their lifespan details: '<h4>History and etymology</h4> <p>The disorder was described in 1969 by the cancer geneticists <strong>Frederick Li</strong> '
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