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Lint: atypical-spindle-cellpleomorphic-lipomatous-tumour

Emphasis
warning

"RB1 deletion"

Line 14:1 · Italics should be used only in exceptional circumstances: '<em>RB1</em>'

"lack of MDM2 or CDK4 amplification"

Line 15:13 · Italics should be used only in exceptional circumstances: '<em>MDM2</em> or <em>CDK4</em>'
Acronyms
warning

"Immunohistochemistry stains can be variably positive for CD34, S100 and desmin and can show a loss of nuclear RB expression in the majority of cases. There is an absence of coexpression of MDM2 and CDK4, however, there can be weak expressions of either one of them 1-5."

Line 41:142 · 'RB' has no definition. Spell it out if it's unfamiliar to the audience.
Oxford Comma
suggestion

"Atypical spindle cell/pleomorphic lipomatous tumours are characterised by a variable amount of atypical spindle cells adipocytes, lipoblasts and pleomorphic or multinucleated cells found in a fibrous and/or myxoid matrix 1-3."

Line 22:122 · Use the Oxford comma in 'adipocytes, lipoblasts and pleomorphic'.

"Immunohistochemistry stains can be variably positive for CD34, S100 and desmin and can show a loss of nuclear RB expression in the majority of cases. There is an absence of coexpression of MDM2 and CDK4, however, there can be weak expressions of either one of them 1-5."

Line 41:71 · Use the Oxford comma in 'CD34, S100 and desmin'.

"form, location and size"

Line 51:5 · Use the Oxford comma in 'form, location and size'.
There Is
suggestion

"Immunohistochemistry stains can be variably positive for CD34, S100 and desmin and can show a loss of nuclear RB expression in the majority of cases. There is an absence of coexpression of MDM2 and CDK4, however, there can be weak expressions of either one of them 1-5."

Line 41:182 · Don't start a sentence with 'There is'.

"Atypical spindle cell/pleomorphic lipomatous tumours are benign lesions and have an excellent prognosis if they are completely excised. The local recurrence rate is about 10-15% 4. There is no known risk of metastases 1-3."

Line 57:196 · Don't start a sentence with 'There is'.