"full brain post-mortem examination demonstrating:"
"Notably, when applied to patients who are asymptomatic or only have cognitive impairment, diagnostic accuracy of the Boston criteria 2.0 is much lower, with a diagnosis of 'probable CAA' only having a sensitivity of 28.6% (95% CI 13.2% to 48.7%) and specificity of 65.3% (95% CI 44.3%–82.8%) 4."
"OR"
"any deep haemorrhagic lesions on T2*-weighted MRI *AND"
"one strictly lobar haemorrhagic lesion on T2*-weighted MRI: intracerebral haemorrhage, cerebral microbleeds, or foci of cortical superficial siderosis or convexity subarachnoid haemorrhage;OR"
"any deep haemorrhagic lesions on T2*-weighted MRI *AND"
"OR"
"any deep haemorrhagic lesions on T2*-weighted MRI *AND"
"one strictly lobar haemorrhagic lesion on T2*-weighted MRI: intracerebral haemorrhage, cerebral microbleeds, or foci of cortical superficial siderosis or convexity subarachnoid haemorrhage;OR"
"any deep haemorrhagic lesions on T2*-weighted MRI *AND"
"In its initial publication, the Boston criteria 2.0 for diagnosis of 'probable CAA' was validated against multiple different cohorts, and against patients who had had autopsy it had a sensitivity of 74.5% (95% confidence interval (CI) 65.4% to 82.4%) and specificity of 95% (95% CI 83.1% to 99.4%), which is superior compared to when the modified Boston criteria were applied to the same patient cohorts 1."
Expected headings
"Criteria"
"Validation"
"The Boston criteria 2.0 were proposed in 2022 in order to better include leptomeningeal and white matter characteristics into the diagnoses of probable and possible cerebral amyloid angiopathy (CAA) 1. They consist of combined clinical, imaging and pathological parameters, and are based upon the original Boston criteria and modified Boston criteria, which were proposed in 1995 and 2010 respectively 2,3."
"one strictly lobar haemorrhagic lesion on T2*-weighted MRI: intracerebral haemorrhage, cerebral microbleeds, or foci of cortical superficial siderosis or convexity subarachnoid haemorrhage;OR"