"Levovist (Bayer AG) 13"
"Definity/Luminity (Lantheus Medical Imaging)"
"Optison (GE Healthcare)"
"Sonazoid (GE Healthcare)"
"Lumason/SonoVue (Bracco)"
"Levovist (Bayer AG) 13"
"Optison (GE Healthcare)"
"Sonazoid (GE Healthcare)"
"In comparison Sonazoid is taken up by Kupffer cells of the liver due to its hydrogenated egg phosphatidylserine sodium coating, leading to persistent contrast enhancement of the liver in the postvascular phase. As metastases to the liver do not contain Kupffer cells, Sonazoid-enhanced US could improve detection and characterisation by demonstrating late-phase hypoenhancement. It can also aid detection of liver tumours such as hepatocellular cancer which typically demonstrates early vascular phase hyperenhancement, whilst the absence of postvascular phase iso/hyperenhancement is a strong indicator of malignant transformation. Thus, Sonazoid could improve differentiation of e.g. regenerative and dysplastic nodules in a cirrhotic liver from early phase hepatocellular carcinomas. As of 2020, Sonazoid is only approved for clinical use in a select few countries 11."
"The microbubbles used for contrast-enhanced ultrasound are sensitive to insonation, and as a consequence can easily be depleted by overscanning during the arterial and portal phase, potentially jeopardizing the detection of e.g. late phase wash-out. This feature can be however also exploited by deliberately destructing them using a single ultrasound pulse with a very high mechanical index, commonly termed "flash" 8. Such an option is nowadays available in most contrast-enhanced ultrasound-capable scanners and allows for the evaluation of slower, e.g. venous phase, contrast refill/reperfusion of a lesion or tissue (termed flash-replenishment technique 9), it can also be used to clear residual contrast signal from the area of interest before a contrast reinjection."
Expected headings
"Non-vascular applications"
"Ultrasound contrast agents"
"First-generation"
"Second-generation"
"Non-targeted CEUS"
"Targeted CEUS"
"used to measure organ perfusion, which can be useful in diagnosing diffuse processes (e.g. cirrhosis)"