"T1: heterogeneous low to intermediate signal"
"T2: heterogeneous high signal with low signal areas"
"STIR/IMFS: high signal with haemorrhagic and hypointense areas"
"T1 C+ (Gd): enhancement of viable tumour and hypointense non-enhancing ossified parts"
"It is of note that native T1 weighted images are considered most accurate in predicting medullary involvement or intraosseous tumour extent 8-12, whereas fluid-sensitive sequences are used for evaluation of soft tissue extension 9,10. Septonodular or rim enhancement suggests a chondroblastic subtype 8,9."
"However, sporadic conventional osteosarcoma is characterised by chromosomal instability and there are a few rare syndromes with germline mutations in RECQ helicases associated with conventional osteosarcoma 1."
"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."
"Usually, tumours are negative for CD31, CD45 and FOS 1."
"Ewing sarcoma"
Expected headings
"Signal characteristics"
"skip lesions and distant metastases (e.g. lung)"
"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."
"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."
"Usually, tumours are negative for CD31, CD45 and FOS 1."
"form, location and size"
"Management consists of wide surgical resection combined with neoadjuvant and postoperative chemotherapy 1-4 with multiple agents 1,13-15 traditionally including methotrexate, adriamycin, cisplatin and ifosfamide. Nowadays limb-salvage techniques are often used. Radiation therapy plays a role in the setting of unresectable tumours 1."