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Lint: conventional-osteosarcoma

Strong List Colon Position
error

"T1: heterogeneous low to intermediate signal"

Line 97:8 · When enboldening an intro, the colon should not be bold. '<strong>T1:</strong> heterogeneous'

"T2: heterogeneous high signal with low signal areas"

Line 98:8 · When enboldening an intro, the colon should not be bold. '<strong>T2:</strong> heterogeneous'

"STIR/IMFS: high signal with haemorrhagic and hypointense areas"

Line 99:8 · When enboldening an intro, the colon should not be bold. '<strong>STIR/IMFS:</strong> high'

"T1 C+ (Gd): enhancement of viable tumour and hypointense non-enhancing ossified parts"

Line 100:8 · When enboldening an intro, the colon should not be bold. '<strong>T1 C+ (Gd):</strong> enhancement'
Citation Punctuation Sup
error

"It is of note that native T1 weighted images are considered most accurate in predicting medullary involvement or intraosseous tumour extent 8-12, whereas fluid-sensitive sequences are used for evaluation of soft tissue extension 9,10. Septonodular or rim enhancement suggests a chondroblastic subtype 8,9."

Line 102:145 · Punctuation after citations should never be superscripted. '<sup>8-12, </sup>'
Acronyms
warning

"However, sporadic conventional osteosarcoma is characterised by chromosomal instability and there are a few rare syndromes with germline mutations in RECQ helicases associated with conventional osteosarcoma 1."

Line 32:154 · 'RECQ' has no definition. Spell it out if it's unfamiliar to the audience.

"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."

Line 73:293 · 'EMA' has no definition. Spell it out if it's unfamiliar to the audience.

"Usually, tumours are negative for CD31, CD45 and FOS 1."

Line 74:53 · 'FOS' has no definition. Spell it out if it's unfamiliar to the audience.
List Caps
warning

"Ewing sarcoma"

Line 136:11 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Headings Valid
warning

Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Signal characteristics"

Line 95:1 · "Signal characteristics" is not a recognised heading for this article type.
Inline EG
suggestion

"skip lesions and distant metastases (e.g. lung)"

Line 25:51 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.
Commas
suggestion

"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."

Line 73:164 · More than 5 commas in a single sentence might make it more difficult to read.
Oxford Comma
suggestion

"On immunohistochemistry conventional osteosarcomas display a broad profile, but without any specificity. Frequently positive antigens include osteocalcin, osteonectin, osteoprotegerin, SATB2, RUNX2, S100, actin and CD99. Conventional osteosarcomas might be also positive for EMA and keratin 1."

Line 73:213 · Use the Oxford comma in 'S100, actin and CD99'.

"Usually, tumours are negative for CD31, CD45 and FOS 1."

Line 74:38 · Use the Oxford comma in 'CD31, CD45 and FOS'.

"form, location and size"

Line 108:8 · Use the Oxford comma in 'form, location and size'.

"Management consists of wide surgical resection combined with neoadjuvant and postoperative chemotherapy 1-4 with multiple agents 1,13-15 traditionally including methotrexate, adriamycin, cisplatin and ifosfamide. Nowadays limb-salvage techniques are often used. Radiation therapy plays a role in the setting of unresectable tumours 1."

Line 125:201 · Use the Oxford comma in 'adriamycin, cisplatin and ifosfamide'.