"presence of H3.3 mutation either by H3-3A/H3-3B analysis or by p.Lys.36Met (K36M) expression"
"On immunohistochemistry diffuse nuclear expression of p.Lys36Met (K36M), an antibody against H3.3B is characteristic 1."
"Chondroblastomas are characterised by a p.Lys36Met substitution on the H3-3B (H3F3B) or less frequently H3-3A (H3F3A) genes 1."
"T1: intermediate signal"
"T2: variable, heterogeneous intermediate signal intensity"
"STIR: high signal"
"T1 C+ (Gd): heterogeneous moderate enhancement together with enhancement of surrounding bone and soft-tissue oedema"
"Chondroblastoma accounts for one of the 'C's in the popular mnemonic for lucent bone lesions FEGNOMASHIC."
"On CT and MRI, the lesion can be categorised as Bone-RADS 4 unless histology has already been obtained 10."
"presence of H3.3 mutation either by H3-3A/H3-3B analysis or by p.Lys.36Met (K36M) expression"
"Chondroblastomas are characterised by a p.Lys36Met substitution on the H3-3B (H3F3B) or less frequently H3-3A (H3F3A) genes 1."
"presence of H3.3 mutation either by H3-3A/H3-3B analysis or by p.Lys.36Met (K36M) expression"
Expected headings
"Signal characteristics"
"Bone scintigraphy"
"Most chondroblastomas occur in the subchondral epiphyseal region of long bones such as the proximal or distal femur, the proximal tibia and the proximal humerus 1-3. They can also occur in the talus, calcaneus, patella and pelvic bones e.g. the acetabulum and less frequently affect the ribs the spine or small bones of hands and feet 1 or the craniofacial skeleton 2,3. They are usually confined to a single bone."