"EBV-SMT are characterised by interlacing fascicles of mildly to moderately pleomorphic atypical spindle cells with plentiful eosinophilic cytoplasm. Presence of necrosis, cellularity and mitotic count will vary."
"T1: intermediate signal, similar to muscle or grey matter"
"T1 C+: vivid usually solid contrast enhancement 3"
"T2: low signal 3"
"DWI/ADC: no diffusion restriction 4"
"perfusion: low rCBV 3"
"EBV-SMT range from indolent leiomyomas to aggressive leiomyosarcomas 1,5. In both cases, co-infection with Ebstein-Barr virus is necessary for diagnosis 1."
"EBV-SMT are characterised by interlacing fascicles of mildly to moderately pleomorphic atypical spindle cells with plentiful eosinophilic cytoplasm. Presence of necrosis, cellularity and mitotic count will vary."
"Unlike sporadic smooth muscle tumours, which tend to occur where there is an abundance of smooth muscle cells, EBV-SMT occur in atypical locations that are normally largely free of smooth muscle 3."
"In approximately half of cases, far more frequently than sporadic smooth muscle tumours, EBV-SMT are multifocal at the time of diagnosis, representing simultaneous multiple primaries rather than metastases 1-3."
"When arising in the central nervous system, EBV-SMTs are most frequently extra-axial dural lesions, most closely resembling meningiomas 3-5."
"Treatment of EBV-SMT is primarily with resection, although radiotherapy and chemotherapy have also been used. In the setting of HIV/AIDS, antiretroviral therapy (ART) is also potentially indicated 1."
"Additional treatment with EBV-specific immunotherapy, demethylating agents and mTOR/AKT inhibitors are being investigated 5."
"Additional treatment with EBV-specific immunotherapy, demethylating agents and mTOR/AKT inhibitors are being investigated 5."
"infections (cryptococcoma, tuberculoma, syphilitic gumma etc..)"
Expected headings
"Histology"
"In the HIV population, they are encountered as non-AIDS-defining cancers in both adult and paediatric populations 1. The age range is therefore defined by the underlying cause of immunosuppression, but they tend to be encountered in young adults (mean age of diagnosis 25 years; range: 2.7 to 49 years) 1. No strong gender predilection has been identified 1."
"EBV-SMT are characterised by interlacing fascicles of mildly to moderately pleomorphic atypical spindle cells with plentiful eosinophilic cytoplasm. Presence of necrosis, cellularity and mitotic count will vary."
"Although they occur almost anywhere in the body, the central nervous system (both intra- and extra-axial) is the most common site of involvement, with the gastrointestinal tract, liver, skin, lungs, pharynx, and larynx also relatively frequently involved 1-3."
"sarcomas (e.g. Kaposi sarcoma)"