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Lint: frontotemporal-brain-sagging-syndrome

Litotes
warning

"In many, neuropsychiatric and cognitive features occur only after a period of symptoms attributable to untreated intracranial hypotension (e.g. orthostatic headache). Importantly, however, a significant proportion of patients with spontaneous intracranial hypotension do not have headaches 4. In these individuals, the diagnosis is harder to make and more closely resembles a neurodegenerative disease."

Line 4:275 · Consider using 'lack(s)' instead of 'not have'
List Caps
warning

"Chiari 1 malformation"

Line 77:7 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Oxford Comma
suggestion

"Patients with frontotemporal brain sagging syndrome present slowly, progressively and heterogeneously with a variety of signs and symptoms."

Line 3:64 · Use the Oxford comma in 'slowly, progressively and heterogeneously'.

"In many, neuropsychiatric and cognitive features occur only after a period of symptoms attributable to untreated intracranial hypotension (e.g. orthostatic headache). Importantly, however, a significant proportion of patients with spontaneous intracranial hypotension do not have headaches 4. In these individuals, the diagnosis is harder to make and more closely resembles a neurodegenerative disease."

Line 4:7 · Use the Oxford comma in 'many, neuropsychiatric and cognitive'.
Inline EG
suggestion

"frontal dysfunction (e.g. apathy, disinhibition, poor planning)"

Line 14:28 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

"cognitive impairment (e.g. memory disturbance)"

Line 15:29 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

"reduced conscious state (e.g. somnolence, drowsiness, even coma)"

Line 16:32 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.