"Classification and nomenclature of vascular and lymphatic malformations have changed over time to reflect an evolving understanding of the pathology and genetic underpinnings. Invasive lymphatic malformations have historically been known as "congenital lymphangiomatosis", "disseminated lymphatiomatosis", "multifocal lymphangiomatosis", or "cystic angiomatosis" 1,5. The terminology reflects an acknowledgement that the underlying lesions are lymphatic malformations, and also non-proliferative lesions (and so terminology with "-osis" is discouraged)."
"Langerhans cell histiocytosis (LCH)"
"Gorham stout disease"
"Generalised lymphatic anomaly, previously known as lymphangiomatosis or cystic angiomatosis, is a systemic condition characterised by multifocal lymphatic malformations with systemic distribution. The distribution of lesions is variable; there can be cutaneous, thoracic and abdominal viscera and osseous involvement."
"Generalised lymphatic anomaly, previously known as lymphangiomatosis or cystic angiomatosis, is a systemic condition characterised by multifocal lymphatic malformations with systemic distribution. The distribution of lesions is variable; there can be cutaneous, thoracic and abdominal viscera and osseous involvement."
"There is overlap in appearance and presentation with Gorham-Stout disease, in which lymphatic malformations classically result in progressive osseous destruction (thus the moniker "disappearing bone disease"). By contrast, the osseous lesions seen in generalised lymphatic anomaly tend to be centred in the medullary space, and are less prone to causing progressive cortical destruction."
"There is not a standard treatment. Surgical resection, radiotherapy, chemotherapy, and sclerotherapy have been used 1. Rare cases have been associated with mortality."
"Visceral involvement is variably present, and most commonly involves the spleen 5. Liver, kidneys, lung, mediastinum, neck, axilla, and retroperitoneum may also be involved."