"Usually one of the earlier adaptive changes of the heart in the response to increased peripheral vascular resistance and systemic hypertension is concentric left ventricular hypertrophy. An increased wall tension stimulates sarcomere proliferation within the myocardium leading to cardiomyocyte hypertrophy and an increase of the wall thickness relative to the left ventricular chamber dimension according to Laplace’s equation 3. Concomitantly an increased deposition of fibrous tissue mainly fibrillar collagen occurs in the extracellular matrix of the heart causing increased stiffness of the myocardium or a decline in myocardial elasticity, thus diastolic dysfunction. A continuously ongoing collagen accumulation eventually leads to a decrease of effective myofibrillar density and failure in transmission of the contractile force of the myocardium and thus systolic dysfunction 2-4. At the point, when the myocardium is no longer capable to compensate for the increased afterload through hypertrophy the ventricle will dilate, at first focally as eccentric hypertrophy then globally and concomitantly ventricular function will decrease 3."
"Electrocardiogram (ECG) might detect atrial fibrillation and arrhythmias. Furthermore, it might show a prolonged terminal inverted P wave suggesting atrial enlargement or QRS voltage increases suggesting left ventricular hypertrophy 3."
"cine SSFP"
"IGRE/PSIR"
"ECV"
"Angiotensin-converting enzyme (ACE) inhibitors, AT1 receptor antagonists and diuretics showed good results in the treatment with regression of left ventricular hypertrophy, myocardial fibrosis and an improvement in diastolic dysfunction 3,4,9,10. Concomitant ischaemic heart disease, heart failure and atrial fibrillation or arrhythmias should be treated accordingly."
"higher native T1 values, higher ECV"
"higher native T1 values, higher ECV, abnormal blood-pool gadolinium kinetics"
Expected headings
"Associations"
"Echocardiography"
"Classical findings on examination include an abnormally sustained, enlarged or displaced apical impulse and an S4 gallop suggesting left ventricular hypertrophy 3."
"aortic root disease (e.g. dilatation)"