"NOTE: This article has been transferred from mritutor.org and was last updated in March 5, 1996. Review and edit pending."
"Gadodiamide (Omniscan, Winthrop Pharm.) is a non-ionic complex with two-fifths of the osmolality of Gd-DTPA. It has a median lethal dose of 34 mmol/kg resulting in a safety ratio of 2-3 times that of Gd-DOTA, and 3-4 times that of Gd-DTPA. No abnormal serum bilirubin levels occur, however elevated serum iron levels occurred with an incidence of 8.2% in one study of 73 patients.The efficacy of this contrast is similar to that of Gd-DTPA 3."
"Gadoteridol "
"NOTE: This article has been transferred from mritutor.org and was last updated in March 5, 1996. Review and edit pending. "
"NOTE: This article has been transferred from mritutor.org and was last updated in March 5, 1996. Review and edit pending."
"Chelates of paramagnetic ions Cr and Gd with EDTA were first used however EDTA was of relatively low stability resulting in toxicity in animals 1. Chelates with a higher stability constant have since been used successfully such as Gd-DTPA."
"Chelates of paramagnetic ions Cr and Gd with EDTA were first used however EDTA was of relatively low stability resulting in toxicity in animals 1. Chelates with a higher stability constant have since been used successfully such as Gd-DTPA."
Expected headings
"Ionics"
"Non-ionics"
"Gadodiamide"
"Gadoteridol "
"Intravenous MRI contrast agent safety"
"Intravenous MRI contrast agents include chelates of paramagnetic ions, both ionic and non-ionic. Gadolinium-based contrast agents (GBCAs) are the most common type. The particulates, sequestered in the liver, spleen, and lymph nodes, the intravascular agents, confined to the blood pool, and tumour specific agents are discussed separately (see bottom)."