"m.11778G>A in the MT-ND4 gene: most common (70-90%) and most severe phenotype"
"m.14484T>C in the MT-ND6 gene: 10-15% and most favourable phenotype"
"m.3460G>A in the MT-ND1 gene: 8-25%"
"Idebenone (an antioxidant analogue of coenzyme Q10) is the only treatment which has demonstrated improvements in vision in Leber hereditary optic neuropathy 21,22. Other treatments, such as vitamin B2 and vitamin C supplementation, may have benefits from one study 13. Gene therapy, namely lenadogene nolparvovec, has shown promise in patients with the m.11778G>A mutation 25."