"Mediastinal teratomas are germ cell tumours located in the anterior mediastinum, representing the most common extra-gonadal germ cell tumours."
"mass effect"
"endocrine functionhormone production, e.g. beta-HCG, insulin"
"rupture"
"Mature teratomas have been associated with:"
"Immature teratomas can be associated with:"
"endocrine functionhormone production, e.g. beta-HCG, insulin"
"Treatment depends on whether the teratoma is mature or immature. In the former, surgical resection is curative. In the latter management depends on alpha-FP levels. If these are elevated then postoperative chemotherapy is usually employed 8."
"fistula(e) formation: aorta, SVC, oesophagus, bronchus"
Expected headings
"Associations"
"Mature teratoma"
"Immature"
"Potential complications include"
"Mediastinal teratomas are germ cell tumours arising from ectopic pluripotent stem cells that failed to migrate from yolk endoderm to the gonad. By definition, they should contain elements from all three embryological layers: endoderm, mesoderm and ectoderm. Frequently, however, elements from only two layers are evident 7 (see teratoma article)."
"Because they originate from primitive cells, they have variable neoplastic potential. Generally, cystic lesions tend to be benign whereas solid lesions tend to be malignant; however the final diagnosis is made histologically."
"Mature teratomas and most immature teratomas are benign tumours, but still, carry a risk of malignancy despite being indolent initially and require close clinical, serological, and radiological follow-up, or surgical excision 4,5,9. There is also a low incidence of malignant transformation of somatic cells (i.e. non-germ cell components) within these tumours, e.g. carcinoma, sarcoma, leukaemia 6."
"Mature teratomas and most immature teratomas are benign tumours, but still, carry a risk of malignancy despite being indolent initially and require close clinical, serological, and radiological follow-up, or surgical excision 4,5,9. There is also a low incidence of malignant transformation of somatic cells (i.e. non-germ cell components) within these tumours, e.g. carcinoma, sarcoma, leukaemia 6."