"T1: variable signal depending on the presence of haemorrhage (variable signal if present depending on the age of the haemorrhage, otherwise low signal) 1,2"
"T2/FLAIR: high signal 1,2"
"DWI/ADC: affected areas show diffusion restriction (high DWI signal, low ADC) in the acute phase 3"
"T1 C+ (Gd): enhancement is variable 2"
"MR spectroscopy: may demonstrate an elevated lactate peak with a diminished N-acetylaspartate peak 7"
"Methanol (CH3OH) is a clear, colourless liquid which is biotransformed in-vivo to formaldehyde and then formic acid; the latter metabolite is primarily responsible for the associated metabolic acidosis as well as the neurologic and ophthalmologic toxicity 4."
"Formic acid binds a haem moiety in the terminal complex of the mitochondrial electron transport chain (cytochrome oxidase) resulting in an inhibition of oxidative metabolism, ATP depletion, and cell death 4,5. The retina, optic nerve, and putamina are particularly vulnerable likely by virtue of their relative metabolic requirements and develop cytotoxic oedema."
"Wernicke encephalopathy"
"Perturbations in vision, known as methanol-induced optic neuropathy, are bilateral and painless, with symptoms ranging from subjective blurred/snowfield vision, to complete, often persistent, blindness 5,9,11. Permanent neurologic sequelae may include a parkinsonian syndrome with bradykinesia, tremors, dementia, and rigidity 8."
"Methanol (CH3OH) is a clear, colourless liquid which is biotransformed in-vivo to formaldehyde and then formic acid; the latter metabolite is primarily responsible for the associated metabolic acidosis as well as the neurologic and ophthalmologic toxicity 4."
"Asymptomatic patients presenting with a potentially significant methanol exposure are typically administered fomepizole 10 (preferred agent) or ethanol while awaiting a confirmatory serum methanol level; these agents prevent the metabolism of methanol, and thereby the production of formic acid, by inhibiting alcohol dehydrogenase 4."