"Non-ossifying fibromas show mutations in KRAS and FGFR1 genes in > 80% of cases 1,2,5."
"stage A:"
"stage B:"
"stage C: progressively sclerotic with ossification beginning at the diaphysis"
"stage D: homogeneous sclerosis or disappearing lesion"
"T1: low signal intensity"
"T2:"
"T1 C+ (Gd): variable"
"NOFs account for the 'N' in the popular mnemonic for lucent bone lesions FEGNOMASHIC."
"The aetiology of sporadic non-ossifying fibromas is not known 1. They might occur in the background of germline mutations resulting in the RAS-MAPK pathway 5 or postzygotic mutations in neurofibromatosis type 1 or Jaffe-Campanacci syndrome 1."
"Non-ossifying fibromas are benign spindle cell tumours of bone containing osteoclast-like giant cells 1-3."
"Langerhans cell histiocytosis"
Expected headings
"Plain radiograph / CT"
"Classification"
"Signal characteristics"
"Bone scintigraphy"
"interspersed giant cells, haemosiderophages and clusters of foamy histiocytes"
"History and etymology"