"Mucosal melanoma of the head and neck, including sinonasal mucosal melanoma are inherently aggressive tumours. In the 8th edition of the AJCC TNM system, all mucosal melanomas of the head and neck are therefore staged as T3 or higher, and fall into stage III or IV at diagnosis (see sinonasal mucosal melanoma staging)"
"Mucosal melanoma of the head and neck, including sinonasal mucosal melanoma are inherently aggressive tumours. In the 8th edition of the AJCC TNM system, all mucosal melanomas of the head and neck are therefore staged as T3 or higher, and fall into stage III or IV at diagnosis (see sinonasal mucosal melanoma staging)"
Expected headings
"PET-CT"
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"These tumours appear as exophyic polyploid lesions of variable pigementation (up to 50% are amelanotic), often with surface ulceration 7. When invasive, they can extend into adjacent bone or cartilage and enter adjacent spaces (e.g. the orbit)."
"Mucosal melanoma is morphologically diverse, often containing multiple cell types within the same tumour. Cells may appear spindled, epithelioid, plasmacytoid, rhabdoid, round, or clear, with some lacking clear differentiation. Epithelioid cells have dense pink cytoplasm and large, irregular nuclei, typically arranged in nests or sheets, while spindled cells form interlacing bundles."
"Nodal or distant metastases (lungs, pleura and liver) are not common at diagnosis (5-15%) 4,6,7."