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Lint: spinocerebellar-ataxia

spinocerebellar-ataxia
Ellipses
warning

"Spinocerebellar ataxias (SCAs) comprise a large and expanding group of neurogenetic diseases characterised by degeneration of the spinal cord and cerebellum. There are over fifty individual spinocerebellar ataxias, referred to sequentially as SCA1, SCA2, ..., etc., roughly in their order of discovery and genetic characterisation 2."

Line 1:276 · Don't use an ellipsis... in written text.
Emphasis
warning

"SCA1: CAG repeat in ATXN1"

Line 9:28 · Italics should be used only in exceptional circumstances: '<em>ATXN1</em>'

"SCA2: CAG repeat in ATXN2"

Line 10:28 · Italics should be used only in exceptional circumstances: '<em>ATXN2</em>'

"SCA3: CAG repeat in ATXN3"

Line 11:28 · Italics should be used only in exceptional circumstances: '<em>ATXN3</em>'

"SCA4: GGC repeat in ZFHX3"

Line 12:28 · Italics should be used only in exceptional circumstances: '<em>ZFHX3</em>'

"SCA6: CAG repeat in CACNA1A"

Line 13:28 · Italics should be used only in exceptional circumstances: '<em>CACNA1A</em>'

"SCA7: CAG repeat in ATXN7"

Line 14:28 · Italics should be used only in exceptional circumstances: '<em>ATXN7</em>'

"SCA8: CTG/CAG repeat in ATXN8/ATXN8OS"

Line 15:32 · Italics should be used only in exceptional circumstances: '<em>ATXN8</em>/<em>ATXN8OS</em>'

"SCA10: ATTCT repeat in ATXN10"

Line 16:31 · Italics should be used only in exceptional circumstances: '<em>ATXN10</em>'

"SCA12: CAG repeat in PPP2R2B"

Line 17:29 · Italics should be used only in exceptional circumstances: '<em>PPP2R2B</em>'

"SCA17: CAG repeat in TBP"

Line 18:29 · Italics should be used only in exceptional circumstances: '<em>TBP</em>'

"SCA27B: GAA repeat in FGF14"

Line 19:30 · Italics should be used only in exceptional circumstances: '<em>FGF14</em>'

"SCA31: TGGAA repeat in BEAN1"

Line 20:31 · Italics should be used only in exceptional circumstances: '<em>BEAN1</em>'

"SCA36: GGCCTG repeat in NOP56"

Line 21:32 · Italics should be used only in exceptional circumstances: '<em>NOP56</em>'

"SCA37: ATTTC repeat in DAB1"

Line 22:31 · Italics should be used only in exceptional circumstances: '<em>DAB1</em>'

"SCA51: CAG repeat in THAP11"

Line 23:29 · Italics should be used only in exceptional circumstances: '<em>THAP11</em>'
Acronyms
warning

"SCA4: GGC repeat in ZFHX3"

Line 12:14 · 'GGC' has no definition. Spell it out if it's unfamiliar to the audience.

"SCA27B: GAA repeat in FGF14"

Line 19:16 · 'GAA' has no definition. Spell it out if it's unfamiliar to the audience.

"SCA31: TGGAA repeat in BEAN1"

Line 20:15 · 'TGGAA' has no definition. Spell it out if it's unfamiliar to the audience.

"SCA37: ATTTC repeat in DAB1"

Line 22:15 · 'ATTTC' has no definition. Spell it out if it's unfamiliar to the audience.

"Although individual spinocerebellar ataxias vary in morphological changes, atrophy of the cerebellum, often vermian, is a relatively constant finding. Extracerebellar regions are also affected, depending on the specific SCA 1. Examples of radiological patterns of involvement include:"

Line 26:231 · 'SCA' has no definition. Spell it out if it's unfamiliar to the audience.
List Caps
warning

"Friedreich ataxia"

Line 41:11 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
There Is
suggestion

"Spinocerebellar ataxias (SCAs) comprise a large and expanding group of neurogenetic diseases characterised by degeneration of the spinal cord and cerebellum. There are over fifty individual spinocerebellar ataxias, referred to sequentially as SCA1, SCA2, ..., etc., roughly in their order of discovery and genetic characterisation 2."

Line 1:179 · Don't start a sentence with 'There are'.
Commas
suggestion

"Spinocerebellar ataxias are inherited autosomal dominant conditions 4. Many, including the common types, are repeat expansion disorders 4. Among the repeat expansion spinocerebellar ataxias, the common forms (i.e. SCA1, SCA2, SCA3, and SCA6) are polyglutamine repeats due to exonic CAG repeats 4,11,16. However, other repeat expansions occur in rarer SCAs 8,11,12,16."

Line 7:215 · More than 5 commas in a single sentence might make it more difficult to read.

"the hot cross bun sign may be seen in SCA1, SCA2, SAC3, SCA6, SCA7, SCA8, SCA34 7"

Line 28:57 · More than 5 commas in a single sentence might make it more difficult to read.

"pontine atrophy may be seen in SCA1, SCA2, SCA3, SCA7, SCA8, SCA13, SCA17, SCA23, SCA34, SCA36, SCA40 7"

Line 29:50 · More than 5 commas in a single sentence might make it more difficult to read.
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