"90% of cases are acquired with autoimmune inactivation of the protease by IgG autoantibodies. Antibodies are detectable in about 75% of acute cases 3. Approximately half of all thrombotic thrombocytopenic purpura patients do not have a clear inciting condition or offending drug; this is known as idiopathic thrombotic thrombocytopenic purpura. However, in the other half, underlying disease (e.g. SLE, HIV, cancer), pregnancy, organ transplantation or drugs (e.g. clopidogrel, ciclosporin A) may cause acquired autoantibodies 3. In roughly 2% of cases, congenital deficiency of ADAMTS13 is the cause of thrombotic thrombocytopenic purpura 3."
"90% of cases are acquired with autoimmune inactivation of the protease by IgG autoantibodies. Antibodies are detectable in about 75% of acute cases 3. Approximately half of all thrombotic thrombocytopenic purpura patients do not have a clear inciting condition or offending drug; this is known as idiopathic thrombotic thrombocytopenic purpura. However, in the other half, underlying disease (e.g. SLE, HIV, cancer), pregnancy, organ transplantation or drugs (e.g. clopidogrel, ciclosporin A) may cause acquired autoantibodies 3. In roughly 2% of cases, congenital deficiency of ADAMTS13 is the cause of thrombotic thrombocytopenic purpura 3."
"neurological symptoms (e.g. weakness, headache, coma)"
"90% of cases are acquired with autoimmune inactivation of the protease by IgG autoantibodies. Antibodies are detectable in about 75% of acute cases 3. Approximately half of all thrombotic thrombocytopenic purpura patients do not have a clear inciting condition or offending drug; this is known as idiopathic thrombotic thrombocytopenic purpura. However, in the other half, underlying disease (e.g. SLE, HIV, cancer), pregnancy, organ transplantation or drugs (e.g. clopidogrel, ciclosporin A) may cause acquired autoantibodies 3. In roughly 2% of cases, congenital deficiency of ADAMTS13 is the cause of thrombotic thrombocytopenic purpura 3."
"90% of cases are acquired with autoimmune inactivation of the protease by IgG autoantibodies. Antibodies are detectable in about 75% of acute cases 3. Approximately half of all thrombotic thrombocytopenic purpura patients do not have a clear inciting condition or offending drug; this is known as idiopathic thrombotic thrombocytopenic purpura. However, in the other half, underlying disease (e.g. SLE, HIV, cancer), pregnancy, organ transplantation or drugs (e.g. clopidogrel, ciclosporin A) may cause acquired autoantibodies 3. In roughly 2% of cases, congenital deficiency of ADAMTS13 is the cause of thrombotic thrombocytopenic purpura 3."