Radiopaedia Helpers

alexander-disease

Strong List Colon Position

error

"T2: increased signal in"

Line 39:4 · When enboldening an intro, the colon should not be bold. 'T2: increased'

"T1 C+ (Gd): enhancement may be seen in the same areas"

Line 46:8 · When enboldening an intro, the colon should not be bold. 'T1 C+ (Gd): enhancement'

"T2/FLAIR: increased T2 signal (representing demyelination) and atrophy affecting multiple regions"

Line 59:4 · When enboldening an intro, the colon should not be bold. 'T2/FLAIR: increased'

"T1 C+ (Gd): patchy enhancement uncommonly seen in adult patients"

Line 66:8 · When enboldening an intro, the colon should not be bold. 'T1 C+ (Gd): patchy'

Biographical Date Spacing

error

"The condition is named after New Zealand pathologist William Stewart Alexander (1919-2013) who first described the condition in a 1949 case report ⁸."

Line 71:57 · In a biographical citation, the date should be correctly spaced: 'William Stewart Alexander (1919'

Acronyms

warning

"adult-onset (AOAD): >12 years"

Line 8:21 · 'AOAD' has no definition. Spell it out if it's unfamiliar to the audience.

Headings Case

warning

"Childhood-onset Alexander disease"

Line 27:5 · 'Childhood-onset Alexander disease' should use sentence-style capitalization.

"Juvenile/adult-onset Alexander disease"

Line 49:5 · 'Juvenile/adult-onset Alexander disease' should use sentence-style capitalization.

Emphasis

warning

"Most cases are sporadic. Familial disease has also been reported, however. A heterozygous mutation in the coding region, mapped to chromosome 17q21, of GFAP, an astrocyte-specific intermediate filament protein, is associated with most cases of infantile sporadic onset."

Line 32:156 · Italics should be used only in exceptional circumstances: 'GFAP'

"Adult-onset Alexander disease (AOAD), which was only recognised with any frequency after GFAP was recognised as the mutation, has markedly different imaging findings and presentation."

Line 50:93 · Italics should be used only in exceptional circumstances: 'GFAP'

"adult leukodystrophies (e.g. adrenomyeloneuropathy, LBSL, CSF1R-related leukoencephalopathy)"

Line 76:90 · Italics should be used only in exceptional circumstances: 'CSF1R'

Headings Valid

warning

Expected headings

H1 Terminology
H1 Usage
H1 Epidemiology
H2 Risk factors
H2 Associations
H1 Clinical presentation
H2 Complications
H1 Diagnosis
H2 Diagnostic criteria
H2 Diagnostic clues
H1 Pathology
H2 Aetiology
H2 Location
H2 Classification
H2 Macroscopic appearance
H2 Microscopic appearance
H2 Immunophenotype
H2 Markers
H2 Genetics
H1 Radiographic features
H2 Plain radiograph
H2 Mammography
H2 Antenatal ultrasound
H2 Transoesophageal echocardiography
H2 Ultrasound
H2 CT
H3 Dual-energy CT
H2 Angiography (DSA)
H2 MRI
H2 CT/MRI
H2 Nuclear medicine
H3 PET-CT
H3 PET-MRI
H1 Radiology report
H1 Treatment and prognosis
H2 Complications
H1 History and etymology
H1 Differential diagnosis
H2 Clinical differential diagnosis
H1 Practical points
H1 See also

"Classification"

Line 2:1 · "Classification" should be H2, not H1.

"Childhood-onset Alexander disease"

Line 27:1 · "Childhood-onset Alexander disease" is not a recognised heading for this article type.

"Clinical presentation"

Line 29:1 · "Clinical presentation" should be H1, not H2.

"Pathology"

Line 31:1 · "Pathology" should be H1, not H2.

"Radiographic features"

Line 34:1 · "Radiographic features" should be H1, not H2.

"MRI"

Line 36:1 · "MRI" should be H2, not H3.

"Juvenile/adult-onset Alexander disease"

Line 49:1 · "Juvenile/adult-onset Alexander disease" is not a recognised heading for this article type.

"Clinical presentation"

Line 51:1 · "Clinical presentation" should be H1, not H2.

"Pathology"

Line 53:1 · "Pathology" should be H1, not H2.

"Radiographic features"

Line 55:1 · "Radiographic features" should be H1, not H2.

"MRI"

Line 56:1 · "MRI" should be H2, not H3.

Oxford Comma

suggestion

"Adult-onset Alexander disease presents with prominent bulbar symptoms (dysphagia, dysphonia or dysarthria), pyramidal pattern of weakness and spasticity, cerebellar ataxia, symptomatic palatal tremor (palatal myoclonus), sleep disturbance, autonomic dysfunction, and/or neuropsychiatric symptoms ^9,10,15."

Line 52:75 · Use the Oxford comma in 'dysphagia, dysphonia or dysarthria'.

Commas

suggestion

Line 52:84 · More than 5 commas in a single sentence might make it more difficult to read.

Inline EG

suggestion

"adult leukodystrophies (e.g. adrenomyeloneuropathy, LBSL, CSF1R-related leukoencephalopathy)"

Line 76:38 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.

Links

leukodystrophies