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"Two nitroheterocyclic drugs are established in treatment of acute Chagas disease: benzidazole at 5 mg/kg/day for 60 days; or nifurtimox at 8–10 mg/kg/day for 60–90 days ¹⁵. Other supportive treatment is dependent on organ involvement ¹²."

Line 93:144 · Use a hyphen-minus ('-') instead of an en-dash ('–').

"Two nitroheterocyclic drugs are established in treatment of acute Chagas disease: benzidazole at 5 mg/kg/day for 60 days; or nifurtimox at 8–10 mg/kg/day for 60–90 days ¹⁵. Other supportive treatment is dependent on organ involvement ¹²."

Line 93:164 · Use a hyphen-minus ('-') instead of an en-dash ('–').

Acronyms

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"Chagas disease is confirmed with serology, microscopy and PCR. Further evaluation is typically required and may include ECG, chest X-ray, echocardiography, Holter monitoring, and barium contrast studies if gastrointestinal symptoms are present ^12,13."

Line 5:62 · 'PCR' has no definition. Spell it out if it's unfamiliar to the audience.

Accepted Abbreviations

warning

"Chagas disease is confirmed with serology, microscopy and PCR. Further evaluation is typically required and may include ECG, chest X-ray, echocardiography, Holter monitoring, and barium contrast studies if gastrointestinal symptoms are present ^12,13."

Line 5:135 · Check the abbreviation form against the style guide: 'X-ray'.

Emphasis

warning

"Chagas disease is caused by the protozoan Trypanosoma cruzi. It is commonly transmitted to humans through contact of infected faeces from the insect vector, triatomine or kissing bug, into an open wound. It is less commonly transmitted via blood transfusion, organ transplants or transplacentally ¹²."

Line 44:46 · Italics should be used only in exceptional circumstances: '<em>Trypanosoma cruzi</em>'

Headings Valid

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Expected headings

H1 Terminology
H1 Usage
H1 Epidemiology
H2 Risk factors
H2 Associations
H1 Clinical presentation
H2 Complications
H1 Diagnosis
H2 Diagnostic criteria
H2 Diagnostic clues
H1 Pathology
H2 Aetiology
H2 Location
H2 Classification
H2 Macroscopic appearance
H2 Microscopic appearance
H2 Immunophenotype
H2 Markers
H2 Genetics
H1 Radiographic features
H2 Plain radiograph
H2 Mammography
H2 Antenatal ultrasound
H2 Transoesophageal echocardiography
H2 Ultrasound
H2 CT
H3 Dual-energy CT
H2 Angiography (DSA)
H2 MRI
H2 CT/MRI
H2 Nuclear medicine
H3 PET-CT
H3 PET-MRI
H1 Radiology report
H1 Treatment and prognosis
H2 Complications
H1 History and etymology
H1 Differential diagnosis
H2 Clinical differential diagnosis
H1 Practical points
H1 See also

"Mucocutaneous manifestations"

Line 24:1 · "Mucocutaneous manifestations" is not a recognised heading for this article type.

"Cardiac manifestations"

Line 26:1 · "Cardiac manifestations" is not a recognised heading for this article type.

"Gastrointestinal manifestations"

Line 29:1 · "Gastrointestinal manifestations" is not a recognised heading for this article type.

"Genitourinary manifestations"

Line 36:1 · "Genitourinary manifestations" is not a recognised heading for this article type.

"CNS manifestations"

Line 38:1 · "CNS manifestations" is not a recognised heading for this article type.

"Echocardiography"

Line 49:1 · "Echocardiography" is not a recognised heading for this article type.

Oxford Comma

suggestion

"Chagas disease is confirmed with serology, microscopy and PCR. Further evaluation is typically required and may include ECG, chest X-ray, echocardiography, Holter monitoring, and barium contrast studies if gastrointestinal symptoms are present ^12,13."

Line 5:37 · Use the Oxford comma in 'serology, microscopy and PCR'.

"commonly asymptomatic, but may also present with hepatosplenomegaly, lymphadenopathy or mucosal oedema at the portal of entry"

Line 13:57 · Use the Oxford comma in 'hepatosplenomegaly, lymphadenopathy or mucosal'.

"Chagas disease is caused by the protozoan Trypanosoma cruzi. It is commonly transmitted to humans through contact of infected faeces from the insect vector, triatomine or kissing bug, into an open wound. It is less commonly transmitted via blood transfusion, organ transplants or transplacentally ¹²."

Line 44:165 · Use the Oxford comma in 'vector, triatomine or kissing'.

"Radiographic features of Chagas disease can be seen on plain films, contrast studies, echocardiography, CT and MRI."

Line 46:90 · Use the Oxford comma in 'echocardiography, CT and MRI'.

Semicolons

suggestion

"Two nitroheterocyclic drugs are established in treatment of acute Chagas disease: benzidazole at 5 mg/kg/day for 60 days; or nifurtimox at 8–10 mg/kg/day for 60–90 days ¹⁵. Other supportive treatment is dependent on organ involvement ¹²."

Line 93:124 · Use semicolons judiciously.

Lint: chagas-disease