"In 1622, the Italian anatomist Gaspare Aselli (1581–1625) was the first to describe lymphatics in the modern era. He was actually researching the recurrent laryngeal nerves in canines when he noted some new white cords in the mesentery that filled after dogs had been fed 10,11,13. His renowned posthumously-published magnus opus, "De lactibus sive lacteis venis", which came out in 1627 described his discovery of this new circulatory system. Although, like Galen, he erroneously asserted that the lymph formed in the pancreas, and was transported to the liver 11."
"Jean Pecquet (1624–1674), a French physician, in 1651, described in detail the cisterna chyli, the latter being named Pecquet's receptacle, in his honour, and also the valves of the thoracic duct. He is credited with showing that the lacteals drained the chyle from the gut to the cisterna chyli, thence to the thoracic duct, and not the liver, as had been thought since Galen's time 11,14."
"Thomas Bartholin (1616–1680), the Danish anatomist, coined the term "vasae lymphaticae", translated as lymphatics, for these vessels, and was the first to distinguish between the chyle-carrying lymphatics draining the GI tract and the systemic lymphatics draining everything else. Bartholin also named the fluid they carried, "lymph" 11. By the end of the 18th century the general arrangement of the lymphatics had been elucidated 10,11."
"Occasionally the lymphatic system is considered with the reticuloendothelial system (RES), with the combined whole termed the lymphoreticular system."
"A portion of the blood entering any tissue capillary bed does not return via the veins but instead forms interstitial fluid in the extracellular space, which is returned to the circulation via the lymphatic vessels (a.k.a. lymphatics), which form the lymph vascular system. When the fluid is in the lymphatic system it is known as lymph. It is known as chyle when specifically referring to the lymph draining the gut and liver, which contains chylomicrons from digested food 13."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The lymphatic capillaries (a.k.a. initial lymphatics or, less commonly, terminal lymphatics) are the smallest vessels in the system and arise in the tissue capillary beds as blind-ending single layer endothelial tubes. Compared to capillaries, the lymphatic capillaries are relatively dilated with greater variability in calibre. Dynamic collapse of the capillaries is prevented by anchoring filaments binding their walls to the surrounding structural tissues 5.Ultrastructurally, the lymphatic endothelium of the capillaries lacks fenestrations with a rather sparse/absent basal lamina. Tight junctions are absent between individual cells of the endothelium 3,4. These cytological features allow larger macromolecules to pass with ease from the extracellular space to the lymphatics, which includes proteins, cellular debris and micro-organisms."
"The lymphatic capillaries (a.k.a. initial lymphatics or, less commonly, terminal lymphatics) are the smallest vessels in the system and arise in the tissue capillary beds as blind-ending single layer endothelial tubes. Compared to capillaries, the lymphatic capillaries are relatively dilated with greater variability in calibre. Dynamic collapse of the capillaries is prevented by anchoring filaments binding their walls to the surrounding structural tissues 5.Ultrastructurally, the lymphatic endothelium of the capillaries lacks fenestrations with a rather sparse/absent basal lamina. Tight junctions are absent between individual cells of the endothelium 3,4. These cytological features allow larger macromolecules to pass with ease from the extracellular space to the lymphatics, which includes proteins, cellular debris and micro-organisms."
"The lymphatic capillaries (a.k.a. initial lymphatics or, less commonly, terminal lymphatics) are the smallest vessels in the system and arise in the tissue capillary beds as blind-ending single layer endothelial tubes. Compared to capillaries, the lymphatic capillaries are relatively dilated with greater variability in calibre. Dynamic collapse of the capillaries is prevented by anchoring filaments binding their walls to the surrounding structural tissues 5.Ultrastructurally, the lymphatic endothelium of the capillaries lacks fenestrations with a rather sparse/absent basal lamina. Tight junctions are absent between individual cells of the endothelium 3,4. These cytological features allow larger macromolecules to pass with ease from the extracellular space to the lymphatics, which includes proteins, cellular debris and micro-organisms."
"The lymphatic capillaries converge to form the collecting lymphatics (or collectors) which have both valves and smooth muscle, with walls similar to veins, although unlike the venous wall, the various tunica layers are harder to distinguish. The number of valves is much greater than in veins."
"In some lymphatic networks, the capillaries merge to form precollector lymphatics first, which are like the capillaries in that they have a simple single-layer endothelial wall, but are distinguished from them by the presence of valves, but no smooth muscle layer."
"The collecting lymphatics then pass into the cortex of local lymph nodes as the afferent lymphatics (prenodal collecting lymphatics). The efferent lymphatics (postnodal collecting lymphatics) leave the nodes, either passing to further nodes in the chain or merging with other efferent lymphatic vessels to form the lymphatic trunks."
"The collecting lymphatics then pass into the cortex of local lymph nodes as the afferent lymphatics (prenodal collecting lymphatics). The efferent lymphatics (postnodal collecting lymphatics) leave the nodes, either passing to further nodes in the chain or merging with other efferent lymphatic vessels to form the lymphatic trunks."
"The collecting lymphatics then pass into the cortex of local lymph nodes as the afferent lymphatics (prenodal collecting lymphatics). The efferent lymphatics (postnodal collecting lymphatics) leave the nodes, either passing to further nodes in the chain or merging with other efferent lymphatic vessels to form the lymphatic trunks."
"The lymphatics start as lymphatic capillaries, which coalesce to form larger precollectors and then collector lymphatic vessels. These collecting vessels merge to form lymphatic trunks, before draining into the two largest trunks a.k.a. the lymphatic ducts (TA: vasa lymphatica majora) or great lymphatic vessels: thoracic duct and right lymphatic duct, on the left and right sides of the body respectively 10."
"The primary function of the lymphatic system is to return exuded capillary fluid and protein to the systemic circulation. Approximately 25-50% of the plasma proteins re-enter the central veins every day from the lymph 3. In the GI tract, the draining lymphatics have a key role in transporting cholesterol and long-chain fatty acids (as chylomicrons) to the liver."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"Thomas Bartholin (1616–1680), the Danish anatomist, coined the term "vasae lymphaticae", translated as lymphatics, for these vessels, and was the first to distinguish between the chyle-carrying lymphatics draining the GI tract and the systemic lymphatics draining everything else. Bartholin also named the fluid they carried, "lymph" 11. By the end of the 18th century the general arrangement of the lymphatics had been elucidated 10,11."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
Expected headings
"Lymphatic vessels"
"Lymphatic capillaries"
"Precollecting and collecting lymphatics"
"Lymphatic trunks"
"Alymphatic organs"
"Functions"
"Related pathology"
"** the brain has a lymphatic system, the glymphatic pathway, however, no true lymphatic vessels have been found; the meninges do have a lymphatic system 8."
"The written historical record likely first describes lymphatics in Classical Greece, when both Hippocrates (c.460-c.370 BCE) and Aristotle (c.384-c.322 BCE) wrote about channels that were likely lymphatic in nature 1. In ancient Egypt, Erasistratus (c.304-c.250 BCE) detailed "milky arteries" in the mesenteric fat 1. Contemporaneously, Galen described lacteals and the thymus. In the 7th century of the common era, the Greek surgeon Paulus Aegineta (625-690) was the first to note infected cervical nodes 13,14."
"Jean Pecquet (1624–1674), a French physician, in 1651, described in detail the cisterna chyli, the latter being named Pecquet's receptacle, in his honour, and also the valves of the thoracic duct. He is credited with showing that the lacteals drained the chyle from the gut to the cisterna chyli, thence to the thoracic duct, and not the liver, as had been thought since Galen's time 11,14."