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Lint: mediastinal-seminoma

Acronyms
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"positivity of OCT4 and KIT/CD117"

Line 17:31 · 'KIT' has no definition. Spell it out if it's unfamiliar to the audience.

"12p abnormalities on FISH studies"

Line 18:29 · 'FISH' has no definition. Spell it out if it's unfamiliar to the audience.

"Clinical signs and symptoms are frequently chest-related and include dyspnoea, chest pain and cough. Systemic symptoms and signs include weight loss, nausea, fever and gynaecomastia 1-3. They might also present with complications such as superior vena cava syndrome or might be found incidentally on imaging studies 1,2. β-hCG and/or LDH might be elevated 1-4, whereas AFP is usually normal 1-4."

Line 21:451 · 'AFP' has no definition. Spell it out if it's unfamiliar to the audience.

"Mediastinal seminomas usually express OCT4, KIT/CD117 and SALL4 on immunohistochemistry stains 1. They are also frequently positive for D2-40, PLAP and CD99 1. Weak positivity for keratins might be observed 1."

Line 51:48 · 'KIT' has no definition. Spell it out if it's unfamiliar to the audience.

"Mediastinal seminomas usually express OCT4, KIT/CD117 and SALL4 on immunohistochemistry stains 1. They are also frequently positive for D2-40, PLAP and CD99 1. Weak positivity for keratins might be observed 1."

Line 51:165 · 'PLAP' has no definition. Spell it out if it's unfamiliar to the audience.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Pathogenesis"

Line 31:1 · "Pathogenesis" is not a recognised heading for this article type.
Oxford Comma
suggestion

"The final diagnosis is based on pathology, gender and the absence of a testicular lesion on imaging 1."

Line 5:36 · Use the Oxford comma in 'pathology, gender and the'.

"small sheets or clusters of polygonal epithelioid cells with a clear, pale or eosinophilic cytoplasm"

Line 9:71 · Use the Oxford comma in 'clear, pale or eosinophilic'.

"Clinical signs and symptoms are frequently chest-related and include dyspnoea, chest pain and cough. Systemic symptoms and signs include weight loss, nausea, fever and gynaecomastia 1-3. They might also present with complications such as superior vena cava syndrome or might be found incidentally on imaging studies 1,2. β-hCG and/or LDH might be elevated 1-4, whereas AFP is usually normal 1-4."

Line 21:161 · Use the Oxford comma in 'nausea, fever and gynaecomastia'.

"Macroscopically mediastinal seminomas are lobulated to nodular tumours with a smooth and shiny cut surface and a white to light tannish colour. Areas of necrosis, haemorrhage or cystic spaces are uncommonly seen 1,4."

Line 36:157 · Use the Oxford comma in 'necrosis, haemorrhage or cystic'.

"confluent sheets, clusters or cords of round to polygonal tumour cells"

Line 40:18 · Use the Oxford comma in 'sheets, clusters or cords'.

"rarely prominent cystic changes, syncytiotrophoblasts or intercellular oedema"

Line 48:32 · Use the Oxford comma in 'changes, syncytiotrophoblasts or intercellular'.

"Mediastinal seminomas usually express OCT4, KIT/CD117 and SALL4 on immunohistochemistry stains 1. They are also frequently positive for D2-40, PLAP and CD99 1. Weak positivity for keratins might be observed 1."

Line 51:161 · Use the Oxford comma in '40, PLAP and CD99'.

"Mediastinal seminomas usually appear as bulky, homogeneous lobular masses. Sometimes they might have cystic, haemorrhagic or necrotic components."

Line 53:105 · Use the Oxford comma in 'cystic, haemorrhagic or necrotic'.
Inline EG
suggestion

"associated complications (e.g. superior vena cava obstruction)"

Line 65:33 · Consider replacing a bracketed e.g. with an inline e.g. after a comma.