"The name of this disease was changed from primary biliary cirrhosis to primary biliary cholangitis in 2014, keeping the acronym PBC 9."
"The name of this disease was changed from primary biliary cirrhosis to primary biliary cholangitis in 2014, keeping the acronym PBC 9."
"PBC should be suspected in patients, in particular middle-aged females, with cholestasis and raised ALP with no other cause identified, with AMA positivity confirming the diagnosis 10,11. Liver biopsy is usually not indicated, but may be considered in patients with suspected AMA-negative PBC 10,11."
"PBC should be suspected in patients, in particular middle-aged females, with cholestasis and raised ALP with no other cause identified, with AMA positivity confirming the diagnosis 10,11. Liver biopsy is usually not indicated, but may be considered in patients with suspected AMA-negative PBC 10,11."
"PBC should be suspected in patients, in particular middle-aged females, with cholestasis and raised ALP with no other cause identified, with AMA positivity confirming the diagnosis 10,11. Liver biopsy is usually not indicated, but may be considered in patients with suspected AMA-negative PBC 10,11."
"liver function tests are elevated, in particular, ALP 10"
Expected headings
"Associations"
"CT / MRI"
"Complications"
"additional risk in older patients, males, presence of cirrhosis, history of diabetes mellitus, or past hepatitis B virus infection 6,15,16"
"hepatomegaly (~30% of cases; range 11-50%) 20"
"typically, PBC affects small intrahepatic bile ducts ("
"common feature in PBC (~75%; range 62-88%), and more in other aetiologies of chronic liver disease 3,20"