"Radiologically isolated syndrome (RIS) describes patients with MRI neuroimaging findings suggesting multiple sclerosis in patients who are asymptomatic or do not have typical symptoms (e.g. headache). Development of typical symptoms in patients with radiologically isolated syndrome is called conversion."
"Patients with radiologically isolated syndrome must not have neurological dysfunction suggestive of multiple sclerosis based on history and physical examination 8,11. Extreme caution should be applied to applying the diagnostic criteria in patients with chronic headache 8."
"While the phenomenon of an asymptomatic, subclinical, or clinically silent disease state of multiple sclerosis, incidentally discovered on autopsy and later imaging studies, has long been known, the extensive availability of MRI has led to a significant number of studies performed for indications other than inflammatory demyelinating disorders of the CNS, giving rise to this syndrome."
"The imaging factors that predict conversion to multiple sclerosis include contrast-enhancing lesions, higher T2 lesion load, presence of infratentorial lesions, and spinal cord lesions 8,11; of these, spinal cord lesions are the best predictor 9,10."
"The imaging factors that predict conversion to multiple sclerosis include contrast-enhancing lesions, higher T2 lesion load, presence of infratentorial lesions, and spinal cord lesions 8,11; of these, spinal cord lesions are the best predictor 9,10."