"A provisional diagnosis can often be made by a combination of clinical examination and imaging, especially MRI 2,7,8, as well as histology 1-3, should there be a doubt after advanced imaging with the collaboration of a multidisciplinary team 2."
"Location "
"T1: low to intermediate signal (iso- to slightly hyperintense vs muscle)"
"T2: high intensity in non-mineralised/calcified portions with or without signal voids"
"GRE/SWI: blooming of mineralised/calcified portions"
"T1 C+ (Gd): heterogeneous moderate to intense contrast enhancement"
"DCE: arterial enhancement within 10s has been reported to favour chondrosarcoma vs enchondroma 11, though specificity is limited"
"DCE: arterial enhancement within 10s has been reported to favour chondrosarcoma vs enchondroma 11, though specificity is limited"
"contrast enhancement pattern (DCE – arterial enhancement)"
"Pre-operative histology carries the risk of tumour seeding within the biopsy tract 6,7,11."
"The terminology depends mainly on localisation. Low-grade tumours arising from the long and short tubular bones of the extremities should be termed ‘central atypical cartilaginous tumours’, whereas tumours arising from the axial skeleton, including the flat bones of the pelvis, scapula and skull base, are called chondrosarcoma grade 1 1-4."
"Individuals with enchondromatosis and a somatic mosaic mutation in IDH1 or IDH2 have a high risk of developing atypical cartilaginous tumours/chondrosarcomas grade 1, especially those with enchondromas in the pelvis or multiple enchondromas in both small and long or flat bones (~46%) 1,10. The risk in patients with multiple enchondromas confined to the hands and feet is substantially lower (~15%) 1,10."
"About 50% of primary and 75-80% of secondary low-grade chondrosarcomas display somatic mutations in the IDH1 and IDH2 genes 1,3."
Expected headings
"Location "
"Associations"
"Plain radiograph/CT"
"Signal characteristics"
"Complications"
"The terminology depends mainly on localisation. Low-grade tumours arising from the long and short tubular bones of the extremities should be termed ‘central atypical cartilaginous tumours’, whereas tumours arising from the axial skeleton, including the flat bones of the pelvis, scapula and skull base, are called chondrosarcoma grade 1 1-4."
"MRI is an important tool in the detection, grading and differentiation of low-grade chondrosarcoma versus enchondroma and intermediate to higher-grade chondrosarcoma, as well as to other bone tumours."
"Central atypical cartilaginous tumours/chondrosarcomas grade 1 (ACT/CS1) are aggressive cartilage matrix-forming tumours evolving from endochondral ossification 1,3. Primary lesions develop without precursor lesions; secondary lesions arise from a pre-existing benign precursor lesion, such as an enchondroma 1."
"History and etymology"