"P: polyneuropathy"
"O: organomegaly"
"E: endocrinopathy"
"M: monoclonal gammopathy"
"S: skin changes"
"POEMS syndrome is the acronymic name for a rare multisystem paraneoplastic disorder including the following features:"
"To make the diagnosis of POEMS syndrome, these features should be temporally related and have no other attributable cause."
"As the diagnostic criteria suggest, the clinical presentation may be broader than just what the acronym "POEMS" suggests."
"AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma syndrome) may be an early indicator 8,9"
"The pathogenesis of POEMS syndrome is not well understood 11. It is thought that proinflammatory cytokines (e.g. VEGF) play a key role 11."
"The bones show sclerotic lesions, usually small ("
"chronic inflammatory demyelinating polyneuropathy is often the initial diagnosis in POEMS syndrome, but in POEMS syndrome the weakness typically minimally involves proximal muscles 4"
"chronic inflammatory demyelinating polyneuropathy is often the initial diagnosis in POEMS syndrome, but in POEMS syndrome the weakness typically minimally involves proximal muscles 4"
"POEM procedure: unrelated procedure involving an oesophageal myomectomy"
"P: polyneuropathy"
"O: organomegaly"
"E: endocrinopathy"
"S: skin changes"
"skin changes, e.g. hyperpigmentation, hypertrichosis, glomeruloid haemangiomata, plethora, acrocyanosis, flushing, or white nails"
"symptoms of organomegaly, e.g. a new palpable mass of lymphadenopathy or Castleman disease, or abdominal discomfort from hepatomegaly or splenomegaly"
"volume overload, e.g. peripheral oedema, ascites, pleural effusion, or pericardial effusion"
"The bones show sclerotic lesions, usually small ("
"The bones show sclerotic lesions, usually small ("
"optic disc swelling (mimicking papilloedema)"
"skin changes (hyperpigmentation, hypertrichosis, glomeruloid haemangiomata, plethora, acrocyanosis, flushing, or white nails)"
"symptoms of endocrinopathy, e.g. hypogonadism (most common), hyperprolactinaemia, hypopituitarism, Addison disease, hyperparathyroidism, hypoparathyroidism, type 2 diabetes mellitus, hyperthyroidism or hypothyroidism"
"skin changes, e.g. hyperpigmentation, hypertrichosis, glomeruloid haemangiomata, plethora, acrocyanosis, flushing, or white nails"
"The bones show sclerotic lesions, usually small ("
"Generally, if systemic, treatment is similar to other clonal plasma cell disorders, such as multiple myeloma, with chemotherapy (e.g. lenalidomide, bortezomib, etc.) and/or autologous haemopoietic stem cell transplant 6. If there is no bone marrow involvement and disease is only local, then radiotherapy to bony lesions may be another treatment option 6. Given the risk of thrombosis, appropriate thromboprophylaxis should also be considered in all patients 10."
"The cardinal clinical feature is a subacute, demyelinating, sensorimotor peripheral polyneuropathy 7. This typically causes marked distal limb weakness, with relative sparing of proximal musculature 7. There is often associated pain, especially distally 7."
"symptoms of endocrinopathy, e.g. hypogonadism (most common), hyperprolactinaemia, hypopituitarism, Addison disease, hyperparathyroidism, hypoparathyroidism, type 2 diabetes mellitus, hyperthyroidism or hypothyroidism"
"The bones show sclerotic lesions, usually small ("