"Epidemiology "
"Clinical presentation "
"MRI "
"If a history is unavailable, blood tests can remain positive for 2 days, urine tests for 2-4 days, and hair for 3 months 6. Patients may test ANCA positive, and p-ANCA autoantibody (especially to human neutrophil elastase) is particularly helpful in distinguishing CIMDLS from the pattern seen in granulomatosis with polyangiitis (GPA)."
"If a history is unavailable, blood tests can remain positive for 2 days, urine tests for 2-4 days, and hair for 3 months 6. Patients may test ANCA positive, and p-ANCA autoantibody (especially to human neutrophil elastase) is particularly helpful in distinguishing CIMDLS from the pattern seen in granulomatosis with polyangiitis (GPA)."
"granulomatosis with polyangiitis (affects heart, lungs and kidneys; often c-ANCA positive)"
Expected headings
"Epidemiology "
"Clinical presentation "
"MRI "
"Cocaine-induced midline destructive lesion (CIMDL), a consequence of snorting cocaine powder, begins with necrosis of the nasal pyramid and can spread to involve adjacent structures including the clivus, craniocervical junction, anterior and middle cranial fossae."
"Cocaine use is widespread and increasing 1; the drug is addictive and tolerance drives dose increases 6. Sporadic use is common and can cause myocardial infarction, arrhythmias and stroke. Regular use can cause cocaine-induced midline destructive lesion, which is dose and duration-dependent. A history of illegal drug use can be difficult to obtain, so the true incidence is unknown."
"Symptoms are due to destruction or secondary infection and include disfigurement, oronasal regurgitation, altered sense of smell and taste, epistaxis and dysphonia."
"granulomatosis with polyangiitis (affects heart, lungs and kidneys; often c-ANCA positive)"
"Cocaine use is widespread and increasing 1; the drug is addictive and tolerance drives dose increases 6. Sporadic use is common and can cause myocardial infarction, arrhythmias and stroke. Regular use can cause cocaine-induced midline destructive lesion, which is dose and duration-dependent. A history of illegal drug use can be difficult to obtain, so the true incidence is unknown."
"granulomatosis with polyangiitis (affects heart, lungs and kidneys; often c-ANCA positive)"