"T1: low signal intensity"
"T2: high signal intensity"
"DWI: high signal intensity on high b-value, low signal intensity on ADC"
"SWI: low signal intensity on the inverted magnitude and phase images 7"
"T1 C+ (Gd): enhancement"
"Osteolytic bone metastases are characterised by destruction and loss of normal bone or bone matrix 1,2, in which parathyroid hormone-related peptide (PTHrP) plays a significant part in the evolution of osteolytic lesions by stimulating the differentiation and activating osteoclasts via the RANKL pathway, which primarily mediates the degradation of bone 1,4,5."
Expected headings
"Signal characteristics"
"Bone scintigraphy"
"MRI is an effective tool for the detection of bone metastases in general and the evaluation of the bone marrow, including the detection and assessment of complications such as pathological fractures or cord compression 2,3. Due to the increased water content, osteolytic bone metastases are nicely depicted on T1, STIR and diffusion-weighted images 3,7. MRI can also reliably differentiate predominantly osteolytic from osteoblastic bone metastases 7."