"Location "
"axial skeleton – peripheral chondrosarcoma grade 1(CS1):"
"T1: low signal or isointense vs muscle"
"T2/STIR: high signal intensity with punctate or curvilinear signal voids indicating matrix mineralisation 9,10"
"T1 C+ (Gd): peripheral and septal enhancement"
"Similar to central atypical cartilaginous tumour/chondrosarcoma grade 1, the terminology depends on the localisation. Tumours in the tubular bones of the appendicular skeleton are called ‘peripheral atypical cartilaginous tumours’, whereas tumours of the axial skeleton are called chondrosarcoma grade 1. This includes low-grade chondrosarcomas of the pelvis, scapula, and skull base 1,2."
"Peripheral atypical cartilaginous tumours/chondrosarcomas grade 1 (ACT/CS1) are locally aggressive cartilage matrix-forming tumours evolving at the surface of bone within the cartilaginous cap of pre-existing osteochondromas, especially in the setting of multiple osteochondromas and EXT1 or EXT2 germline mutations 1,3."
"Individuals with osteochondromas in particular multiple osteochondromas and germline mutations in EXT1 or EXT2 are at risk of tumour progression to secondary peripheral chondrosarcoma 1. Estimated risk:"
"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."
"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."
"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."
"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."
Expected headings
"Location "
"Plain radiograph/CT"
"Signal characteristics"
"Complications"
"History and etymology"