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Lint: peripheral-atypical-cartilaginous-tumour-low-grade-peripheral-chondrosarcoma-2

Headings Spacing
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"Location "

Line 28:1 · Never put spaces at either end of headings.
En Dash
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"axial skeleton peripheral chondrosarcoma grade 1(CS1):"

Line 32:19 · Use a hyphen-minus ('-') instead of an en-dash ('–').
Strong List Colon Position
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"T1: low signal or isointense vs muscle"

Line 86:8 · When enboldening an intro, the colon should not be bold. '<strong>T1:</strong> low'

"T2/STIR: high signal intensity with punctate or curvilinear signal voids indicating matrix mineralisation 9,10"

Line 87:8 · When enboldening an intro, the colon should not be bold. '<strong>T2/STIR:</strong> high'

"T1 C+ (Gd): peripheral and septal enhancement"

Line 88:8 · When enboldening an intro, the colon should not be bold. '<strong>T1 C+ (Gd): </strong>peripheral'
Strong
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"Similar to central atypical cartilaginous tumour/chondrosarcoma grade 1, the terminology depends on the localisation. Tumours in the tubular bones of the appendicular skeleton are called ‘peripheral atypical cartilaginous tumours’, whereas tumours of the axial skeleton are called chondrosarcoma grade 1. This includes low-grade chondrosarcomas of the pelvis, scapula, and skull base 1,2."

Line 3:165 · Generally, don't use bold in text: 'of the appendicular skeleton are called ‘peripheral atypical cartilaginous tumours’,<strong> </strong>whereas tumours of the axial skeleton are called chondrosarcoma grade 1. This includes low-grade chondrosarcomas of the pelvis, scapula, and skull base'
Emphasis
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"Peripheral atypical cartilaginous tumours/chondrosarcomas grade 1 (ACT/CS1) are locally aggressive cartilage matrix-forming tumours evolving at the surface of bone within the cartilaginous cap of pre-existing osteochondromas, especially in the setting of multiple osteochondromas and EXT1 or EXT2 germline mutations 1,3."

Line 21:288 · Italics should be used only in exceptional circumstances: '<em>EXT1</em> or <em>EXT2</em>'

"Individuals with osteochondromas in particular multiple osteochondromas and germline mutations in EXT1 or EXT2 are at risk of tumour progression to secondary peripheral chondrosarcoma 1. Estimated risk:"

Line 23:102 · Italics should be used only in exceptional circumstances: '<em>EXT1</em> or <em>EXT2</em>'

"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."

Line 68:83 · Italics should be used only in exceptional circumstances: '<em>EXT1</em> or <em>EXT2</em> with a proportion of <em>EXT1</em> or <em>EXT2</em> mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression <sup>1,2</sup>. Mutations in cell-cycle regulatory genes such as <em>CDKN2A</em>'
Acronyms
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"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."

Line 68:186 · 'EXT' has no definition. Spell it out if it's unfamiliar to the audience.

"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."

Line 68:226 · 'EXT' has no definition. Spell it out if it's unfamiliar to the audience.

"Secondary peripheral chondrosarcomas are associated with germline mutations in EXT1 or EXT2 with a proportion of EXT1 or EXT2 mutations among all EXT alleles of about 40% and coexisting EXT-mutant and EXT-wildtype cells. The wild-type cells are thought to be the cell type prone to tumour progression 1,2. Mutations in cell-cycle regulatory genes such as CDKN2A are also thought to be involved 1."

Line 68:241 · 'EXT' has no definition. Spell it out if it's unfamiliar to the audience.
Headings Valid
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Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Location "

Line 28:1 · "Location " is not a recognised heading for this article type.

"Plain radiograph/CT"

Line 71:1 · "Plain radiograph/CT" is not a recognised heading for this article type.

"Signal characteristics"

Line 84:1 · "Signal characteristics" is not a recognised heading for this article type.

"Complications"

Line 111:1 · "Complications" is under the wrong parent heading (found under "Treatment and prognosis").
Biographical Lifespan
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"History and etymology"

Line 113:1 · A bold element in the History and etymology section should be a person; it would be useful to have their lifespan details: '<h4>History and etymology</h4> <p>Chondrosarcomas in general were first described by the American bone pathologists <strong>Louis Liechtenstein</strong> '