"genetics (HLA- DR2, DR3, B8) 20"
"Most patients demonstrate at least one type of autoantibody, typically anti-smooth muscle antibody (ASMA) and antinuclear antibody (ANA), which are seen in up to 75%. p-ANCA is also positive in up to 80% of patients with primary sclerosing cholangitis 19."
"autoimmune hepatitis (AIH-PSC overlap)"
"MRCP and ERCP"
"ERCP has traditionally been the gold standard for the depiction of the biliary tree, and also offers the ability to perform cholangioplasty, if necessary. In practice, however, MRCP is used before ERCP since it is non-invasive, can assess the liver, and avoids the 10% risk of hospitalisation from ERCP in primary sclerosing cholangitis patients 17."
"ERCP has traditionally been the gold standard for the depiction of the biliary tree, and also offers the ability to perform cholangioplasty, if necessary. In practice, however, MRCP is used before ERCP since it is non-invasive, can assess the liver, and avoids the 10% risk of hospitalisation from ERCP in primary sclerosing cholangitis patients 17."
"ERCP has traditionally been the gold standard for the depiction of the biliary tree, and also offers the ability to perform cholangioplasty, if necessary. In practice, however, MRCP is used before ERCP since it is non-invasive, can assess the liver, and avoids the 10% risk of hospitalisation from ERCP in primary sclerosing cholangitis patients 17."
"Cholangioplasty of dominant strictures is usually performed in a retrograde fashion via ERCP or via a transhepatic approach 6,7."
"Riedel thyroiditis"
Expected headings
"Associations"
"MRCP and ERCP"
"Complications"
"The average age of diagnosis of primary sclerosing cholangitis is 54 years (range 6-93), with increased occurrence in men (63%) 15. A large number of asymptomatic individuals are identified upon investigation of persistently deranged liver function tests. Symptomatic individuals commonly present non-specifically with fatigue. More specific symptoms include pruritus, jaundice or gastrointestinal bleeding 16."
"No medical therapy has stood the test of time, with ursodeoxycholic acid, immunosuppression, chelation and antifibrinolytic therapy unable to demonstrate consistent benefits over placebo 8."
"IgG4 levels 4x normal; ratio of IgG4 to IgG1 of >0.24 17"